144745 20240826140055.0 10.1055/s-0035-1552630 doi 0302-4350 ISSN 1431-4886 ISSN 1438-9428 ISSN DZNE-2020-00195 610 Fischer, A. P:(DE-2719)2000047 0 First author dzne Epigenetik – neue Erkenntnisse zum Verständnis neurodegenerativer Erkrankungen | Epigenetic Mechanisms in Neurodegenerative Diseases Stuttgart 2015 Thieme online Crossref Georg Thieme Verlag KG 2015-09-14 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1724673602_18923 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Epigenetics describes the various structures and functions of the DNA-protein matrix (chromatin), which regulate gene expression beyond the DNA sequence. The epigenome determines the differences in the development of genetically identical cells and individuals (mono-zygotic twins). Epigenetic features such as direct biochemical modifications of DNA (methylation) are affected by environmental conditions (famine, early life stress) and are inherited in a modified form, without alteration of the DNA sequence. The analysis of epigenetic processes, in particular DNA methylation, modifications of the DNA-binding proteins, and the functions of the non-coding microRNA, opens an unexpectedly complex field of environment-gene interactions that affect the individual patterns of disease symptoms as well as effects and side effects of many drugs.The study of the epigenome hold the promise of new diagnostic and possibly therapeutic perspectives also for the two most common neurodegenerative diseases, namely Alzheimerʼs and Parkinsonʼs disease. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 1 Dataset connected to CrossRef Schneider, A. P:(DE-2719)2812035 1 dzne Wüllner, U. P:(DE-2719)2000056 2 Last author dzne 10.1055/s-0035-1552630 : Georg Thieme Verlag KG, 2015-09-14 07 393-401 journal-article Crossref Aktuelle Neurologie 42 2015 0302-4350 10.1055/s-0035-1552630 Vol. 42, no. 07, p. 393 - 401 PERI:(DE-600)2056721-2 07 393-401 Aktuelle Neurologie 42 2015 0302-4350 VDB oai:pub.dzne.de:144745 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2000047 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2812035 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2000056 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 1 2015 Nationallizenz StatID:(DE-HGF)0420 StatID 2019-12-21 ger DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2019-12-21 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2019-12-21 WoS StatID:(DE-HGF)0112 StatID Emerging Sources Citation Index 2019-12-21 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2019-12-21 I:(DE-2719)1011302 AG Wüllner Biomarker Parkinson's Disease 0 I:(DE-2719)1410002 AG Fischer ; AG Fischer Epigenetics and Systems Medicine in Neurodegenerative Diseases 1 I:(DE-2719)1440011 AG Schneider Göttingen Translational Dementia Research Göttingen 2 journal VDB I:(DE-2719)1011302 I:(DE-2719)1410002 I:(DE-2719)1440011 UNRESTRICTED