145046 20250415092455.0 10.1002/mds.27964 doi pmid:31951049 pmid 0885-3185 ISSN 1531-8257 ISSN altmetric:74188526 altmetric DZNE-2020-00406 English 610 Piot, Ines P:(DE-2719)9000949 0 First author dzne The Progressive Supranuclear Palsy Clinical Deficits Scale. New York, NY 2020 Wiley online Crossref Wiley 2020-01-17 print Crossref Wiley 2020-04-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1744701853_3743 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote There is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes.To develop a scale to monitor clinical deficits in patients with PSP across its broad phenotypes.The Progressive Supranuclear Palsy Clinical Deficits Scale was conceptualized to cover seven clinical domains (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait & balance), each scored from 0 to 3 (no, mild, moderate, or severe deficits). User guidelines were developed to standardize its application. Progressive Supranuclear Palsy Clinical Deficits Scale scores were collected in patients fulfilling the MDS-PSP diagnostic criteria in two independent, multicenter, observational studies, both cross-sectionally (exploratory DescribePSP cohort; confirmatory ProPSP cohort) and longitudinally (12-months' follow-up, both cohorts).Cognitive pretesting demonstrated easy scale utility. In total, 164 patients were scored (70.4 ± 7.6 years; 62% males, 35% variant phenotypes). Mean Progressive Supranuclear Palsy Clinical Deficits Scale completion time was 4 minutes. The Progressive Supranuclear Palsy Clinical Deficits Scale total score correlated with existing scales (e.g., Progressive Supranuclear Palsy Rating Scale: R = 0.88; P < 0.001). Individual Progressive Supranuclear Palsy Clinical Deficits Scale items correlated well with similar constructs in existing scales. Internal consistency (Cronbach's alpha: 0.75), inter-rater reliability (0.96), and test-retest stability (0.99) were acceptable. The PSP-CDS showed significant 12-month change (baseline, 8.6 ± 3.6; follow-up: 10.8 ± 3.6; annualized difference: 3.4 ± 3.4; n = 49; P < 0.0001). Sample sizes required per arm for a two-arm, 1-year follow-up therapeutic trial to detect 50% change in Progressive Supranuclear Palsy Clinical Deficits Scale progression was estimated to be 65 (two-sided, two-sample t test).The Progressive Supranuclear Palsy Clinical Deficits Scale is a rapidly completed, clinimetrically sound scale for clinical care and research involving PSP. © 2020 International Parkinson and Movement Disorder Society. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2020-01-17 Crossref http://onlinelibrary.wiley.com/termsAndConditions#vor 2020-01-17 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Disease Progression MeSH Female MeSH Fingers MeSH Humans MeSH Male MeSH Motor Skills MeSH Reproducibility of Results MeSH Supranuclear Palsy, Progressive: diagnosis MeSH Schweyer, Kerstin P:(DE-2719)2811446 1 dzne Respondek, Gesine P:(DE-2719)2811600 2 dzne Stamelou, Maria P:(DE-HGF)0 3 group, DescribePSP study P:(DE-HGF)0 4 Collaboration Author group, ProPSP study P:(DE-HGF)0 5 Collaboration Author group, MDS-endorsed PSP study P:(DE-HGF)0 6 Collaboration Author Sckopke, Philipp P:(DE-HGF)0 7 Schenk, Thomas P:(DE-HGF)0 8 Goetz, Christopher G P:(DE-HGF)0 9 Stebbins, Glenn T P:(DE-HGF)0 10 Höglinger, Günter P:(DE-2719)2811373 11 Last author dzne Gasser, Thomas P:(DE-HGF)0 12 Hermann, Andreas P:(DE-HGF)0 13 Höglinger, Günter P:(DE-HGF)0 14 Höllerhage, Matthias P:(DE-HGF)0 15 Kimmich, Okka P:(DE-HGF)0 16 Klockgether, Thomas P:(DE-HGF)0 17 Levin, Johannes P:(DE-HGF)0 18 Machetanz, Gerrit P:(DE-HGF)0 19 Osterrath, Antje P:(DE-HGF)0 20 Palleis, Carla P:(DE-HGF)0 21 Prudlo, Johannes P:(DE-HGF)0 22 Spottke, Annika P:(DE-HGF)0 23 Berg, Daniela P:(DE-HGF)0 24 Bürk, Katrin 25 Claßen, Joseph 26 Eggers, Carsten 27 Greuel, Andrea 28 Grimm, Max-Joseph P:(DE-HGF)0 29 Hermann, Lennard 30 Iankova, Vassilena 31 Jahn, Klaus 32 Jost, Wolfgang 33 Klietz, Martin 34 Kühn, Andrea P:(DE-HGF)0 35 Marxreiter, Franz 36 Paschen, Steffen 37 Poetter-Nerger, Monika 38 Preisl, Marie-Therese 39 Prilop, Lisa 40 Tönges, Lars 41 Trenkwalder, Claudia 42 Warnecke, Tobias 43 Wegner, Florian 44 Winkler, Jürgen 45 Antonini, Angelo 46 P, Kailash P 47 L, Adam L 48 Colosimo, Carlo 49 Compta, Yaroslau 50 Corvol, Jean-Christophe 51 I, Lawrence I 52 Höglinger, Günter U P:(DE-HGF)0 53 E, Anthony E 54 Litvan, Irene 55 R, Huw R 56 Nilsson, Christer 57 Pantelyat, Alexander 58 Respondek, Gesine P:(DE-HGF)0 59 Stamelou, Maria 60 10.1002/mds.27964 : Wiley, 2020-01-17 4 650-661 journal-article Crossref Movement Disorders 35 2020 0885-3185 10.1002/mds.27964 Vol. 35, no. 4, p. 650 - 661 PERI:(DE-600)2041249-6 4 650-661 Movement disorders 35 2020 0885-3185 http://pub.dzne.de/record/145046/files/DZNE-2020-00406_Restricted.pdf http://pub.dzne.de/record/145046/files/DZNE-2020-00406_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:145046 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9000949 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2811446 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811600 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 11 P:(DE-2719)2811373 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2020 DEAL Wiley StatID:(DE-HGF)3001 StatID 2020-02-26 ger DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2020-02-26 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-11 ger JCR StatID:(DE-HGF)0100 StatID MOVEMENT DISORD : 2021 2022-11-11 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-11 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-11 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-11 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-11 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-11 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-11 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - 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