145124 20240321221029.0 10.1016/j.bbr.2019.112110 doi pmid:31340173 pmid 0166-4328 ISSN 1872-7549 ISSN altmetric:64190232 altmetric DZNE-2020-00483 English 610 Maaß, Sarah C P:(DE-2719)9001252 0 First author dzne Timing deficiencies in amnestic Mild Cognitive Impairment: Disentangling clock and memory processes. Amsterdam 2019 Elsevier print Crossref Elsevier BV 2019-11-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709651631_29110 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Interval timing performance in cognitive decline is typically characterized by decreased accuracy, precision, or both. One explanation for this decreased performance is a larger clock time variability. However, memory deficiencies associated with cognitive decline might also affect temporal performance in two alternative ways: First, memory deficiencies could lead to reduced encoding of just perceived durations, and thus a stronger reliance on the memory traces of previous experiences (the 'prior'), yielding less precise reproductions of the most current experiences. Second, memory deficiencies could hamper the storage of perceived intervals, thus resulting in less influence of the prior. Here, we present data of 15 patients with amnestic Mild Cognitive Impairment (aMCI) and 44 healthy, aged controls, the latter split in two groups based on memory performance. All participants were tested on a temporal production task to assess clock time variability and a multi-duration reproduction task to assess the influence of memory traces reflecting current and previous experiences. Patients with aMCI showed the strongest regression towards the mean in a multi-duration reproduction task, followed by low-performing healthy controls and high-performing healthy controls, respectively. As no difference was observed between the groups in terms of clock time variability, and clock variability did not statistically contribute to the observed regression, this increased central tendency effect was not attributable to clock noise. We therefore, in line with the first explanation, conclude that memory deficiencies result in a stronger (relative) reliance on the prior. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2019-11-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ 2019-07-23 Crossref http://creativecommons.org/licenses/by/4.0/ Dataset connected to CrossRef, PubMed, Aged MeSH Aged, 80 and over MeSH Amnesia: psychology MeSH Cognition: physiology MeSH Cognitive Dysfunction: physiopathology MeSH Cognitive Dysfunction: psychology MeSH Female MeSH Humans MeSH Male MeSH Memory: physiology MeSH Middle Aged MeSH Neuropsychological Tests MeSH Reaction Time: physiology MeSH Time Perception: physiology MeSH Riemer, Martin P:(DE-2719)2813753 1 Wolbers, Thomas P:(DE-2719)2810583 2 van Rijn, Hedderik P:(DE-HGF)0 3 10.1016/j.bbr.2019.112110 : Elsevier BV, 2019-11-01 112110 journal-article Crossref Behavioural Brain Research 373 2019 0166-4328 10.1016/j.bbr.2019.112110 Vol. 373, p. 112110 - PERI:(DE-600)2013604-3 112110 Behavioural brain research 373 2019 0166-4328 http://pub.dzne.de/record/145124/files/DZNE-2020-00483.pdf OpenAccess http://pub.dzne.de/record/145124/files/DZNE-2020-00483.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:145124 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9001252 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2813753 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2019 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-17 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-17 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-17 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2020-01-16 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-17 JCR StatID:(DE-HGF)0100 StatID BEHAV BRAIN RES : 2021 2022-11-17 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-17 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-17 IF < 5 StatID:(DE-HGF)9900 StatID 2022-11-17 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-17 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2020-01-16 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-17 ger DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-17 I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 0 I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 1 journal VDB I:(DE-2719)5000006 I:(DE-2719)1310002 UNRESTRICTED FullTexts