151578 20240423115945.0 pmc:PMC7250899 pmc 10.1038/s41467-020-15805-9 doi altmetric:82749629 altmetric pmid:32457293 pmid DZNE-2020-01162 English 500 Stangl, Matthias P:(DE-2719)2810620 0 First author dzne Sources of path integration error in young and aging humans [London] 2020 Nature Publishing Group UK online Crossref Springer Science and Business Media LLC 2020-05-26 print Crossref Springer Science and Business Media LLC 2020-12-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1713781627_6653 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Path integration plays a vital role in navigation: it enables the continuous tracking of one's position in space by integrating self-motion cues. Path integration abilities vary widely across individuals, and tend to deteriorate in old age. The specific causes of path integration errors, however, remain poorly characterized. Here, we combine tests of path integration performance in participants of different ages with an analysis based on the Langevin equation for diffusive dynamics, which allows us to decompose errors into distinct causes that can corrupt path integration computations. We show that, across age groups, the dominant error source is unbiased noise that accumulates with travel distance not elapsed time, suggesting that the noise originates in the velocity input rather than within the integrator. Age-related declines are primarily traced to a growth in this noise. These findings shed light on the contributors to path integration error and the mechanisms underlying age-related navigational deficits. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2020-05-26 Crossref https://creativecommons.org/licenses/by/4.0 Dataset connected to CrossRef Adult MeSH Aged MeSH Cognitive Aging: physiology MeSH Distance Perception: physiology MeSH Female MeSH Humans MeSH Male MeSH Middle Aged MeSH Models, Neurological MeSH Spatial Memory: physiology MeSH Spatial Navigation: physiology MeSH Spatial Processing: physiology MeSH Walking: physiology MeSH Young Adult MeSH Kanitscheider, Ingmar 1 Riemer, Martin P:(DE-2719)2813753 2 dzne Fiete, Ila 0000-0003-4738-2539 3 Wolbers, Thomas P:(DE-2719)2810583 4 Last author dzne 10.1038/s41467-020-15805-9 : Springer Science and Business Media LLC, 2020-05-26 1 2626 journal-article Crossref Nature Communications 11 2020 2041-1723 10.1038/s41467-020-15805-9 Vol. 11, no. 1, p. 2626 PERI:(DE-600)2553671-0 1 2626 Nature Communications 11 2020 2041-1723 https://www.nature.com/articles/s41467-020-15805-9 http://pub.dzne.de/record/151578/files/DZNE-2020-01162.pdf OpenAccess http://pub.dzne.de/record/151578/files/DZNE-2020-01162.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:151578 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810620 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2813753 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2020 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-11 Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ 2020-01-16 DBCoverage 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