153289 20240420115848.0 pmc:PMC7260219 pmc 10.1038/s41398-020-0842-6 doi altmetric:83105966 altmetric pmid:32472038 pmid DZNE-2020-01286 English 610 Schmaal, Lianne 0000-0001-9822-048X 0 Corresponding author ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing London 2020 Nature Publishing Group article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1713533456_11032 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 Dataset connected to CrossRef Brain: diagnostic imaging MeSH Depression MeSH Depressive Disorder, Major: diagnostic imaging MeSH Humans MeSH Information Dissemination MeSH Neuroimaging MeSH Pozzi, Elena 1 C. Ho, Tiffany 2 van Velzen, Laura S. 3 Veer, Ilya M. 4 Opel, Nils 5 Van Someren, Eus J. W. 6 Han, Laura K. M. 0000-0001-9647-3723 7 Aftanas, Lybomir 8 Aleman, André 9 Baune, Bernhard T. 10 Berger, Klaus 11 Blanken, Tessa F. 12 Capitão, Liliana 0000-0003-3117-5156 13 Couvy-Duchesne, Baptiste 14 R. Cullen, Kathryn 15 Dannlowski, Udo 16 Davey, Christopher 0000-0003-1431-3852 17 Erwin-Grabner, Tracy 18 Evans, Jennifer 19 Frodl, Thomas P:(DE-HGF)0 20 Fu, Cynthia H. Y. 21 Godlewska, Beata 22 Gotlib, Ian H. 23 Goya-Maldonado, Roberto 24 Grabe, Hans P:(DE-2719)2811781 25 dzne Groenewold, Nynke A. 26 Grotegerd, Dominik 27 Gruber, Oliver P:(DE-HGF)0 28 Gutman, Boris A. 29 Hall, Geoffrey B. 30 Harrison, Ben J. 31 Hatton, Sean N. 0000-0002-9149-8726 32 Hermesdorf, Marco 33 Hickie, Ian B. 34 Hilland, Eva 35 Irungu, Benson 36 Jonassen, Rune 37 Kelly, Sinead 38 Kircher, Tilo 39 Klimes-Dougan, Bonnie 40 Krug, Axel 0000-0002-0564-2497 41 Landrø, Nils Inge 42 Lagopoulos, Jim 43 Leerssen, Jeanne 44 Li, Meng 45 Linden, David E. J. 0000-0002-5638-9292 46 MacMaster, Frank P. 47 M. McIntosh, Andrew 0000-0002-0198-4588 48 Mehler, David M. A. 49 Nenadić, Igor 50 Penninx, Brenda W. J. H. 51 Portella, Maria J. 52 Reneman, Liesbeth 53 Rentería, Miguel E. 0000-0003-4626-7248 54 Sacchet, Matthew D. 55 G. Sämann, Philipp 56 Schrantee, Anouk 57 Sim, Kang 0000-0003-3209-9626 58 Soares, Jair C. 59 Stein, Dan J. 0000-0001-7218-7810 60 Tozzi, Leonardo 0000-0002-9429-6476 61 van Der Wee, Nic J. A. 62 van Tol, Marie-José 0000-0002-9260-5490 63 Vermeiren, Robert 64 Vives-Gilabert, Yolanda 65 Walter, Henrik 0000-0002-9403-6121 66 Walter, Martin 67 Whalley, Heather C. 0000-0002-4505-8869 68 Wittfeld, Katharina 69 Whittle, Sarah 70 Wright, Margaret J. 0000-0001-7133-4970 71 Yang, Tony T. 72 Zarate, Carlos 73 Thomopoulos, Sophia I. 74 Jahanshad, Neda 0000-0003-4401-8950 75 Thompson, Paul M. 76 Veltman, Dick J. 77 10.1038/s41398-020-0842-6 Vol. 10, no. 1, p. 172 PERI:(DE-600)2609311-X 1 172 Translational Psychiatry 10 2020 2158-3188 https://www.nature.com/articles/s41398-020-0842-6 http://pub.dzne.de/record/153289/files/DZNE-2020-01286.pdf OpenAccess http://pub.dzne.de/record/153289/files/DZNE-2020-01286.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:153289 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 25 P:(DE-2719)2811781 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2020 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-18 Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ 2020-08-28 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-18 JCR StatID:(DE-HGF)0100 StatID TRANSL PSYCHIAT : 2021 2022-11-18 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-02-14T16:19:47Z WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2020-08-28 DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-02-14T16:19:47Z DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-18 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-18 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2021-02-14T16:19:47Z Article Processing Charges StatID:(DE-HGF)0561 StatID 2020-08-28 IF >= 5 StatID:(DE-HGF)9905 StatID TRANSL PSYCHIAT : 2021 2022-11-18 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2020-08-28 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2022-11-18 Fees StatID:(DE-HGF)0700 StatID 2020-08-28 I:(DE-2719)7000000 U Clinical Researchers - Magdeburg U Clinical Researchers - Magdeburg 0 I:(DE-2719)5000001 AG Grabe Biomarkers of Dementia in the General Population 1 journal VDB UNRESTRICTED I:(DE-2719)7000000 I:(DE-2719)5000001 FullTexts