153300 20231206134346.0 journal VDB I:(DE-2719)1011004 I:(DE-2719)1013019 I:(DE-2719)1013005 UNRESTRICTED FullTexts DRIVER article DataCite Output Types/Journal article PUB:(DE-HGF)16 PUB:(DE-HGF) Journal Article journal journal 1701855795_2030 BibTeX ARTICLE ORCID JOURNAL_ARTICLE 0 EndNote Journal Article P:(DE-2719)2811044 Mittag, Manuel 1 P:(DE-2719)2812689 Musacchio, Fabrizio 2 P:(DE-HGF)0 Justus, Lena C 3 P:(DE-HGF)0 Giovannetti, Eleonora Ambrad 4 P:(DE-2719)2810279 Steffen, Julia 5 P:(DE-2719)2662292 Wagner, Jens 6 Zohren, Lioba 7 Schoch, Susanne 8 P:(DE-HGF)0 Schmidt, Boris 9 P:(DE-2719)2810253 Jackson, Walker S 10 P:(DE-2719)2289209 Ehninger, Dan 11 P:(DE-2719)2679991 Fuhrmann, Martin 12 Last author DZNE-2020-01297 http://pub.dzne.de/record/153300/files/DZNE-2020-01297.pdf Published on 2020-06-08. Available in OpenAccess from 2021-06-08. StatID:(DE-HGF)0510 http://pub.dzne.de/record/153300/files/DZNE-2020-01297.pdf?subformat=pdfa pdfa Published on 2020-06-08. Available in OpenAccess from 2021-06-08. StatID:(DE-HGF)0510 In Alzheimer's disease (AD), hippocampus-dependent memories underlie an extensive decline. The neuronal ensemble encoding a memory, termed engram, is partially recapitulated during memory recall. Artificial activation of an engram can restore memory in a mouse model of early AD, but its fate and the factors that render the engram nonfunctional are yet to be revealed. Here, we used repeated two-photon in vivo imaging to analyze fosGFP transgenic mice (which express enhanced GFP under the Fos promoter) performing a hippocampus-dependent memory task. We found that partial reactivation of the CA1 engram during recall is preserved under AD-like conditions. However, we identified a novelty-like ensemble that interfered with the engram and thus compromised recall. Mimicking a novelty-like ensemble in healthy mice was sufficient to affect memory recall. In turn, reducing the novelty-like signal rescued the recall impairment under AD-like conditions. These findings suggest a novel mechanistic process that contributes to the deterioration of memories in AD. NLM Chemicals Amyloid beta-Protein Precursor NLM Chemicals Proto-Oncogene Proteins c-fos MeSH Alzheimer Disease: genetics MeSH Alzheimer Disease: metabolism MeSH Alzheimer Disease: physiopathology MeSH Amyloid beta-Protein Precursor: genetics MeSH Amyloid beta-Protein Precursor: metabolism MeSH Animals MeSH Disease Models, Animal MeSH Female MeSH Hippocampus: physiology MeSH Male MeSH Mental Recall: physiology MeSH Mice MeSH Mice, Transgenic MeSH Neurons: physiology MeSH Optogenetics MeSH Proto-Oncogene Proteins c-fos: genetics MeSH Proto-Oncogene Proteins c-fos: metabolism StatID:(DE-HGF)0200 StatID DBCoverage SCOPUS 2022-11-12 StatID:(DE-HGF)0300 StatID DBCoverage Medline 2022-11-12 StatID:(DE-HGF)1050 StatID DBCoverage BIOSIS Previews 2022-11-12 StatID:(DE-HGF)1190 StatID DBCoverage Biological Abstracts 2020-09-30 StatID:(DE-HGF)0600 StatID DBCoverage Ebsco Academic Search 2022-11-12 StatID:(DE-HGF)0530 StatID Embargoed OpenAccess StatID:(DE-HGF)0100 StatID JCR NAT NEUROSCI : 2021 2022-11-12 StatID:(DE-HGF)0113 StatID WoS Science Citation Index Expanded 2020-09-30 StatID:(DE-HGF)1030 StatID DBCoverage Current Contents - Life Sciences 2022-11-12 StatID:(DE-HGF)0150 StatID DBCoverage Web of Science Core Collection 2022-11-12 StatID:(DE-HGF)0510 StatID OpenAccess StatID:(DE-HGF)0030 StatID Peer Review ASC 2022-11-12 StatID:(DE-HGF)0514 StatID Green Open Access StatID:(DE-HGF)9925 StatID IF >= 25 NAT NEUROSCI : 2021 2022-11-12 StatID:(DE-HGF)0160 StatID DBCoverage Essential Science Indicators 2020-09-30 StatID:(DE-HGF)0420 StatID Nationallizenz 2022-11-12 ger StatID:(DE-HGF)0199 StatID DBCoverage Clarivate Analytics Master Journal List 2022-11-12 2020 I:(DE-588)1065079516 P:(DE-2719)2810397 Deutsches Zentrum für Neurodegenerative Erkrankungen 0 DZNE I:(DE-588)1065079516 P:(DE-2719)2811044 Deutsches Zentrum für Neurodegenerative Erkrankungen 1 DZNE I:(DE-588)1065079516 P:(DE-2719)2812689 Deutsches Zentrum für Neurodegenerative Erkrankungen 2 DZNE I:(DE-588)1065079516 P:(DE-HGF)0 Deutsches Zentrum für Neurodegenerative Erkrankungen 3 DZNE I:(DE-588)1065079516 P:(DE-HGF)0 Deutsches Zentrum für Neurodegenerative Erkrankungen 4 DZNE I:(DE-588)1065079516 P:(DE-2719)2810279 Deutsches Zentrum für Neurodegenerative Erkrankungen 5 DZNE I:(DE-588)1065079516 P:(DE-2719)2662292 Deutsches Zentrum für Neurodegenerative Erkrankungen 6 DZNE I:(DE-588)1065079516 P:(DE-2719)2810253 Deutsches Zentrum für Neurodegenerative Erkrankungen 10 DZNE I:(DE-588)1065079516 P:(DE-2719)2289209 Deutsches Zentrum für Neurodegenerative Erkrankungen 11 DZNE I:(DE-588)1065079516 P:(DE-2719)2679991 Deutsches Zentrum für Neurodegenerative Erkrankungen 12 DZNE G:(DE-HGF)POF3-342 G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-300 G:(DE-HGF)POF3 G:(DE-HGF)POF DE-HGF Gesundheit Erkrankungen des Nervensystems Disease Mechanisms and Model Systems 0 G:(DE-HGF)POF4-899 G:(DE-HGF)POF4-890 G:(DE-HGF)POF4-800 G:(DE-HGF)POF4 G:(DE-HGF)POF DE-HGF Programmungebundene Forschung ohne Programm ohne Topic 0 PERI:(DE-600)1494955-6 10.1038/s41593-020-0652-4 Vol. 23, no. 8, p. 952 - 958 8 952 - 958 Nature neuroscience 23 1546-1726 2020 610 Dataset connected to CrossRef, PubMed, Memory trace interference impairs recall in a mouse model of Alzheimer's disease. doi 10.1038/s41593-020-0652-4 pmid pmid:32514139 ISSN 1097-6256 ISSN 1546-1726 altmetric altmetric:83634112 datacite_doi 10.60944/dzne-2020-01297 New York, NY Nature America 2020 P:(DE-2719)2810397 Poll, Stefanie 0 First author English oai:pub.dzne.de:153300 openaire open_access VDB driver dnbdelivery G:(DE-HGF)POF3-342 342 - Disease Mechanisms and Model Systems (POF3-342) POF3-342 POF III 0 I:(DE-2719)1011004 AG Fuhrmann Neuroimmunology and Imaging 0 I:(DE-2719)1013019 AG Jackson Selective Vulnerability of Neurodegenerative Diseases 1 I:(DE-2719)1013005 AG Ehninger Translational Biogerontology 2