153422 20230915094021.0 10.5414/NP301278 doi DZNE-2020-01419 English 610 Riemenschneider, Markus J. 0 Quality assurance in neuropathology: Experiences from the round robin trials on IDH mutation and MGMT promoter methylation testing launched by the Quality Assurance Initiative Pathology (QuIP) in 2018 and 2019 Deisenhofen, München 2020 Dustri-Verl. article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1606486947_22902 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote We here report on the first neuropathological round robin trials initiated by the Quality Assurance Initiative Pathology (QuIP) in Germany in the years 2018 and 2019. Testing services as external laboratory controls were offered for IDH1-R132H immunohistochemistry in 2018 followed by a molecular trial for IDH1 and IDH2 mutations in 2019 including the rare mutational variants. Also in 2019, a trial on MGMT promoter methylation testing was offered. On a national scale, trial offers were well received with around 40 participating institutions. The international announcement of the molecular IDH1/IDH2 mutational trial achieved only moderate European outspread. Success rates in all three trials were excellent (IDH1-R132H immunohistochemistry 2018: 94%, 18 out of 20 possible points required; IDH1/IDH2 mutational status 2019: 100%, 19 out of 20 possible points required; MGMT promoter methylation 2019: 94%, 19 out of 20 possible points required) indicating that quality standards are high in the broad majority of the institutions. Trial participation also involved filling in a questionnaire asking for background information on local testing procedures. We here present a first assessment of the information collected providing unique insights in the landscape of molecular testing in neuropathology. Derived from this information we identify future challenges and provide an outlook on the development of quality assurance in the field of neuropathology. 345 - Population Studies and Genetics (POF3-345) G:(DE-HGF)POF3-345 POF3-345 POF III 0 Dataset connected to CrossRef Fischer, Josephine 1 Grassow-Narlik, Maja 2 Mawrin, Christian 3 Deimling, Andreas von 4 Pietsch, Torsten P:(DE-2719)2812617 5 dzne Reifenberger, Guido 6 Mueller, Wolf C. 7 Sommer, Clemens J. 8 Dietel, Manfred 9 Zoubaa, Saida 10 Lorenz, Julia P:(DE-HGF)0 11 Corresponding author Rothhammer-Hampl, Tanja P:(DE-HGF)0 12 Corresponding author 10.5414/NP301278 Vol. 39, no. 09, p. 203 - 211 PERI:(DE-600)2007408-6 09 203 - 211 Clinical neuropathology 39 2020 0722-5091 oai:pub.dzne.de:153422 VDB Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2812617 DE-HGF Forschungsbereich Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-345 G:(DE-HGF)POF3-300 Population Studies and Genetics 0 2020 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2020-08-21 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2020-08-21 JCR StatID:(DE-HGF)0100 StatID CLIN NEUROPATHOL : 2019 2021-01-27 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2021-01-27 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2021-01-27 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2021-01-27 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2021-01-27 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2021-01-27 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2021-01-27 IF < 5 StatID:(DE-HGF)9900 StatID 2021-01-27 I:(DE-2719)1011009 Brainbank Unit Bonn Brainbank Unit Bonn 0 journal VDB I:(DE-2719)1011009 UNRESTRICTED