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000153434 1001_ $$00000-0002-7482-2758$$aLiu, Kathy Y.$$b0$$eCorresponding author
000153434 245__ $$aNoradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences
000153434 260__ $$a[London]$$bNature Publishing Group UK$$c2020
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000153434 520__ $$aThe locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.
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000153434 650_2 $$2MeSH$$aAdolescent
000153434 650_2 $$2MeSH$$aAdrenergic Neurons: physiology
000153434 650_2 $$2MeSH$$aAdult
000153434 650_2 $$2MeSH$$aAged
000153434 650_2 $$2MeSH$$aAged, 80 and over
000153434 650_2 $$2MeSH$$aAging: genetics
000153434 650_2 $$2MeSH$$aAging: physiology
000153434 650_2 $$2MeSH$$aBehavior: physiology
000153434 650_2 $$2MeSH$$aBiobehavioral Sciences
000153434 650_2 $$2MeSH$$aCognition: physiology
000153434 650_2 $$2MeSH$$aCognitive Aging: physiology
000153434 650_2 $$2MeSH$$aCohort Studies
000153434 650_2 $$2MeSH$$aFemale
000153434 650_2 $$2MeSH$$aHumans
000153434 650_2 $$2MeSH$$aLatent Class Analysis
000153434 650_2 $$2MeSH$$aLocus Coeruleus: diagnostic imaging
000153434 650_2 $$2MeSH$$aLocus Coeruleus: physiology
000153434 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000153434 650_2 $$2MeSH$$aMagnetoencephalography
000153434 650_2 $$2MeSH$$aMale
000153434 650_2 $$2MeSH$$aMiddle Aged
000153434 650_2 $$2MeSH$$aNeurodegenerative Diseases: genetics
000153434 650_2 $$2MeSH$$aYoung Adult
000153434 7001_ $$00000-0003-0700-4568$$aKievit, Rogier A.$$b1
000153434 7001_ $$aTsvetanov, Kamen A.$$b2
000153434 7001_ $$0P:(DE-2719)2810555$$aBetts, Matthew J.$$b3$$udzne
000153434 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b4$$udzne
000153434 7001_ $$aRowe, James B.$$b5
000153434 7001_ $$aHoward, Robert$$b6
000153434 7001_ $$0P:(DE-2719)2811927$$aHämmerer, Dorothea$$b7$$eLast author$$udzne
000153434 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-15410-w$$gVol. 11, no. 1, p. 1712$$n1$$p1712$$tNature Communications$$v11$$x2041-1723$$y2020
000153434 8564_ $$uhttps://www.nature.com/articles/s41467-020-15410-w
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