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@ARTICLE{Liu:153434,
      author       = {Liu, Kathy Y. and Kievit, Rogier A. and Tsvetanov, Kamen A.
                      and Betts, Matthew J. and Düzel, Emrah and Rowe, James B.
                      and Howard, Robert and Hämmerer, Dorothea},
      title        = {{N}oradrenergic-dependent functions are associated with
                      age-related locus coeruleus signal intensity differences},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-01431},
      pages        = {1712},
      year         = {2020},
      abstract     = {The locus coeruleus (LC), the origin of noradrenergic
                      modulation of cognitive and behavioral function, may play an
                      important role healthy ageing and in neurodegenerative
                      conditions. We investigated the functional significance of
                      age-related differences in mean normalized LC signal
                      intensity values (LC-CR) in magnetization-transfer (MT)
                      images from the Cambridge Centre for Ageing and Neuroscience
                      (Cam-CAN) cohort - an open-access, population-based dataset.
                      Using structural equation modelling, we tested the
                      pre-registered hypothesis that putatively noradrenergic
                      (NA)-dependent functions would be more strongly associated
                      with LC-CR in older versus younger adults. A unidimensional
                      model (within which LC-CR related to a single factor
                      representing all cognitive and behavioral measures) was a
                      better fit with the data than the a priori two-factor model
                      (within which LC-CR related to separate NA-dependent and
                      NA-independent factors). Our findings support the concept
                      that age-related reduction of LC structural integrity is
                      associated with impaired cognitive and behavioral function.},
      keywords     = {Adolescent / Adrenergic Neurons: physiology / Adult / Aged
                      / Aged, 80 and over / Aging: genetics / Aging: physiology /
                      Behavior: physiology / Biobehavioral Sciences / Cognition:
                      physiology / Cognitive Aging: physiology / Cohort Studies /
                      Female / Humans / Latent Class Analysis / Locus Coeruleus:
                      diagnostic imaging / Locus Coeruleus: physiology / Magnetic
                      Resonance Imaging / Magnetoencephalography / Male / Middle
                      Aged / Neurodegenerative Diseases: genetics / Young Adult},
      cin          = {AG Düzel / AG Speck},
      ddc          = {500},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1340009},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7136271},
      pubmed       = {pmid:32249849},
      doi          = {10.1038/s41467-020-15410-w},
      url          = {https://pub.dzne.de/record/153434},
}