Home > Publications Database > Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences > print

001     153434
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100 1 _ |a Liu, Kathy Y.
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245 _ _ |a Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences
260 _ _ |a [London]
|c 2020
|b Nature Publishing Group UK
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520 _ _ |a The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.
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650 _ 2 |a Adolescent
|2 MeSH
650 _ 2 |a Adrenergic Neurons: physiology
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Aging: genetics
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Behavior: physiology
|2 MeSH
650 _ 2 |a Biobehavioral Sciences
|2 MeSH
650 _ 2 |a Cognition: physiology
|2 MeSH
650 _ 2 |a Cognitive Aging: physiology
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Latent Class Analysis
|2 MeSH
650 _ 2 |a Locus Coeruleus: diagnostic imaging
|2 MeSH
650 _ 2 |a Locus Coeruleus: physiology
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Magnetoencephalography
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: genetics
|2 MeSH
650 _ 2 |a Young Adult
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700 1 _ |a Kievit, Rogier A.
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700 1 _ |a Tsvetanov, Kamen A.
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700 1 _ |a Betts, Matthew J.
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700 1 _ |a Düzel, Emrah
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700 1 _ |a Rowe, James B.
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700 1 _ |a Howard, Robert
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700 1 _ |a Hämmerer, Dorothea
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773 _ _ |a 10.1038/s41467-020-15410-w
|g Vol. 11, no. 1, p. 1712
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856 4 _ |u https://www.nature.com/articles/s41467-020-15410-w
856 4 _ |u https://pub.dzne.de/record/153434/files/DZNE-2020-01431.pdf
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