154186 20240219124743.0 pmid:32814083 pmid 10.1016/j.mad.2020.111327 doi 0047-6374 ISSN 1872-6216 ISSN DZNE-2021-00048 English 610 Lountzi, Dimitra P:(DE-2719)2812559 0 First author dzne Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice Amsterdam [u.a.] 2020 Elsevier Science article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1708343226_1852 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Experiments using heterochronic parabionts, i.e. young and old animals connected surgically and hence developing a shared circulation, have shown that blood-borne factors, transferred from young to old mice and vice versa, play a role in influencing a range of health outcomes associated with advanced age. Previous work has explored the contributory role of plasma-derived factors in mediating such parabiotic effects, including those on aging-associated neural and behavioural impairments. Here, we wanted to identify possible influences that blood-borne cellular factors may have on age-related behavioural phenotypes. Towards this end, we subjected old BALB/c H-2d mice to repetitive non-myeloablative bone marrow transplants (BMT) from young donor animals and assessed effects on behaviour and cognition. We detected expected age-related alterations in our behavioural assays but did not discern any obvious differences between old BMT mice and old control animals. Our study represents the first to look at possible behavioural and cognitive effects of heterochronic, non-myeloablative BMT. Future work should extend this study by including additional behavioural tests in the analysis, addressing whether beneficial effects of BMT may be detectable on other genetic backgrounds and reconciling our findings with those achieved by myeloablative BMT. 341 - Molecular Signaling (POF3-341) G:(DE-HGF)POF3-341 POF3-341 POF III 0 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 1 Dataset connected to CrossRef Aging MeSH Allografts MeSH Animals MeSH Behavior, Animal MeSH Bone Marrow Transplantation MeSH Mice MeSH Mice, Inbred BALB C MeSH Henzel, Kristin P:(DE-2719)2810479 1 dzne Jazbec, Katerina 2 Bano, Daniele P:(DE-2719)2158358 3 dzne Krauss, Sybille P:(DE-2719)2421562 4 dzne Rožman, Primož 5 Ehninger, Dan P:(DE-2719)2289209 6 Last author dzne 10.1016/j.mad.2020.111327 Vol. 191, p. 111327 - PERI:(DE-600)1502520-2 111327 Mechanisms of ageing and development 191 2020 0047-6374 https://www.sciencedirect.com/science/article/abs/pii/S0047637420301238?via%3Dihub http://pub.dzne.de/record/154186/files/DZNE-2021-00048_Restricted.pdf http://pub.dzne.de/record/154186/files/DZNE-2021-00048_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:154186 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2812559 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810479 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2158358 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2421562 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2289209 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-341 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Molecular Signaling 0 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 1 DE-HGF Programmungebundene Forschung ohne Programm G:(DE-HGF)POF4-890 G:(DE-HGF)POF4-899 G:(DE-HGF)POF4 G:(DE-HGF)POF4-800 G:(DE-HGF)POF ohne Topic 0 2020 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-01-26 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-01-26 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-01-26 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-22 ger DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-22 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-22 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-22 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-22 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-22 JCR StatID:(DE-HGF)0100 StatID MECH AGEING DEV : 2021 2022-11-22 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-22 IF >= 5 StatID:(DE-HGF)9905 StatID MECH AGEING DEV : 2021 2022-11-22 I:(DE-2719)1013003 AG Bano Aging and Neurodegeneration 0 I:(DE-2719)1011006 AG Krauß Regulatory RNA-protein interaction in neurodegenerative diseases 1 I:(DE-2719)1013005 AG Ehninger Translational Biogerontology 2 journal VDB I:(DE-2719)1013003 I:(DE-2719)1011006 I:(DE-2719)1013005 UNRESTRICTED