154348 20250417133750.0 10.1002/ana.25901 doi pmid:32935385 pmid 0364-5134 ISSN 1531-8249 ISSN altmetric:90341071 altmetric DZNE-2021-00202 English 610 Tetreault, Aaron M 0 Network Localization of Alien Limb in Patients with Corticobasal Syndrome. Hoboken, NJ 2020 Wiley-Blackwell article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1744889821_17132 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote ISSN 1531-8249 not unique: **3 hits**. Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific versus progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside the perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS-specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion-induced disorders to symptom-specific brain networks. Here, we use a similar technique termed 'atrophy network mapping' to localize single-subject atrophy maps to symptom-specific brain networks.Single-subject atrophy maps were generated by comparing cortical thickness in patients with CBS versus controls. Next, we performed seed-based functional connectivity using a large normative connectome to determine brain regions functionally connected to each patient's atrophied locations.Patients with CBS had perirolandic atrophy versus controls at the group level, but locations of atrophy in CBS were heterogeneous outside of the perirolandic cortex at the single-subject level (mean spatial correlation = 0.04). In contrast, atrophy occurred in locations functionally connected to the perirolandic cortex in all patients with CBS (spatial correlation = 0.66). Compared with PSP, patients with CBS had atrophy connected to a network of higher-order sensorimotor regions beyond perirolandic cortex, matching a CBS atrophy network from a recent meta-analysis. Finally, atrophy network mapping identified a symptom-specific network for alien limb, matching a lesion-induced alien limb network and a network associated with agency in healthy subjects.We identified a syndrome-specific network for CBS and symptom-specific network for alien limb using single-subject atrophy maps and the human connectome. ANN NEUROL 2020;88:1118-1131. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Alien Limb Phenomenon: pathology MeSH Aged MeSH Alien Hand Syndrome: pathology MeSH Atrophy: pathology MeSH Case-Control Studies MeSH Cerebral Cortex: pathology MeSH Connectome MeSH Humans MeSH Male MeSH Middle Aged MeSH Supranuclear Palsy, Progressive: pathology MeSH Syndrome MeSH Phan, Tony 1 Petersen, Kalen J 2 Claassen, Daniel O P:(DE-HGF)0 3 Neth, Byran J P:(DE-HGF)0 4 Graff-Radford, Jonathan P:(DE-HGF)0 5 Albrecht, Franziska 6 Fliessbach, Klaus P:(DE-HGF)0 7 Schneider, Anja P:(DE-2719)2812035 8 dzne Synofzik, Matthis 9 Diehl-Schmid, Janine 10 Otto, Markus 11 Schroeter, Matthias L 12 Darby, Richard Ryan P:(DE-HGF)0 13 Corresponding author Initiative, 4 Repeat Tau Neuroimaging 14 Collaboration Author 10.1002/ana.25901 Vol. 88, no. 6, p. 1118 - 1131 PERI:(DE-600)2037912-2 6 1118 - 1131 Annals of neurology 88 2020 1531-8249 http://pub.dzne.de/record/154348/files/DZNE-2021-00202_Restricted.pdf http://pub.dzne.de/record/154348/files/DZNE-2021-00202_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:154348 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)2812035 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Programmungebundene Forschung ohne Programm G:(DE-HGF)POF4-890 G:(DE-HGF)POF4-899 G:(DE-HGF)POF4 G:(DE-HGF)POF4-800 G:(DE-HGF)POF ohne Topic 0 2020 DEAL Wiley StatID:(DE-HGF)3001 StatID 2021-02-03 ger DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-02-03 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-02-03 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-02-03 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-30 ger JCR StatID:(DE-HGF)0100 StatID ANN NEUROL : 2021 2022-11-30 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-30 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-30 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-30 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-30 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-30 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-30 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-30 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2022-11-30 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-30 IF >= 10 StatID:(DE-HGF)9910 StatID ANN NEUROL : 2021 2022-11-30 I:(DE-2719)1440011 AG Schneider Göttingen Translational Dementia Research Göttingen 0 journal VDB I:(DE-2719)1440011 UNRESTRICTED