Journal Article

DZNE-2021-00235

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.

Markaki, I. (Corresponding author) ; Bergström, S. ; Tsitsi, P. ; Remnestål, J. ; Månberg, A. ; Hertz, E. ; Paslawski, W. ; Sorjonen, K. ; Uhlén, M. ; Mangone, G. ; Carvalho, S. ; Rascol, O. ; Meissner, W. G. ; Magnin, E. ; Wüllner, U.DZNE* ; Corvol, J.-C. ; Nilsson, P. ; Svenningsson, P.

2020
Wiley New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/mds.28192

Abstract: Cognitive impairment is common in patients with PD. Core markers of Alzheimer's dementia have been related also to PD dementia, but no disease-specific signature to predict PD dementia exists to date.The aim of this study was to investigate CSF markers associated with cognition in early PD.A high-throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini-Mental State Examination.Of 69 patients with complete data, 34 had high (≥90) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (<90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen-1, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders.Kininogen-1 levels in CSF may serve as a marker of cognitive impairment in PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Cognition Disorders: diagnosis (MeSH) ; Cognition Disorders: etiology (MeSH) ; Cognitive Dysfunction: etiology (MeSH) ; Humans (MeSH) ; Kininogens (MeSH) ; Mental Status and Dementia Tests (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson's disease ; cognition ; kininogen-1 ; neurodegeneration

Note: ISSN 1531-8257 not unique: **3 hits**.

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Contributing Institute(s):

1. Biomarkers for Parkinson's disease (AG Wüllner ; AG Wüllner 2)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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