Journal Article

DZNE-2021-00832

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Abnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson's disease-a fNIRS study.

Hofmann, A. (First author)DZNE* ; Rosenbaum, D. ; Int-Veen, I. ; Ehlis, A.-C. ; Brockmann, K.DZNE* ; Dehnen, K. ; von Thaler, A.-K.DZNE* ; Berg, D.Extern* ; Fallgatter, A. J.DZNE* ; Metzger, F.Extern* ; Consortium, T. S. (Collaboration Author)

2021
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neurobiolaging.2021.04.014

Abstract: Parkinson's Disease (PD) is a neurodegenerative disorder leading to typical motor as well as a range of non-motor symptoms, including cognitive decline mainly characterized by executive deficits. The latter are known to appear years before the typical motor signs, thus representing the prodromal phase of PD. However, appropriate methods for measuring executive dysfunction in this context are not well established yet. Traditionally, executive performance is associated with frontal structures. Here, we investigated prodromal, early PD patients and healthy controls regarding their executive functioning on the behavioral and neural level, measured by the Trail-Making-Test (TMT) combined with functional near-infrared spectroscopy. We observed significantly reduced neural activity in the right dorsolateral prefrontal cortex within PD patients compared to controls completing the TMT-A and -B in contrast to the TMT-C, but no differences on a behavioral level. These promising results need to be confirmed and checked for reliability in future studies to extend the spectrum of markers applied in prodromal PD.

Keyword(s): Aged (MeSH) ; Executive Function (MeSH) ; Female (MeSH) ; Frontal Lobe: physiopathology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: physiopathology (MeSH) ; Parkinson Disease: psychology (MeSH) ; Reproducibility of Results (MeSH) ; Spectroscopy, Near-Infrared (MeSH) ; Executive dysfunction ; Functional Near-Infrared Spectroscopy (fNIRS) ; Parkinson's disease ; Prodromal stage

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Contributing Institute(s):

1. Core ICRU (Core ICRU)
2. Parkinson Genetics (AG Gasser 1)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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