Journal Article (Review Article)

DZNE-2021-01118

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry.

Hansen, N. ; Luedecke, D. ; Malchow, B. ; Lipp, M. ; Vogelgsang, J. ; Timäus, C. ; Zindler, T. ; Gingele, S. ; Kühn, S. ; Gallinat, J. ; Wiedemann, K. ; Denk, J. ; Moschny, N. ; Fiehler, J. ; Skripuletz, T. ; Riedel, C. ; Wattjes, M. P. ; Zerr, I.Extern* ; Esselmann, H. ; Poustka, L. ; Karow, A. ; Hartmann, H. ; Frieling, H. ; Bleich, S. ; Wiltfang, J.DZNE* ; Neyazi, A. ; CAP, +. (Collaboration Author)

2021
Springer Wien [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00702-021-02354-8

Abstract: Studies show that psychiatric symptoms in adults and children are sometimes associated with serum neural autoantibodies. The significance of serum neural autoantibodies associated with psychiatric symptoms in children remains often unclear, but might be relevant for the extent and occurrence of psychiatric disease manifestation in later life, as well as therapy and outcome. For this narrative review, we sought articles listed in PubMed and published between 1988 and 2020 addressing the maternal-fetal transfer of neural autoantibodies and psychiatric disorders associated with serum neural autoantibodies. We identified six major subgroups of psychiatric disorders in children that are associated with serum neural autoantibodies: patients with attentional deficit hyperactivity disorder, autism spectrum disorder, obsessive compulsive disorder, Gilles de la Tourette syndrome, psychosis and catatonia. Furthermore, we summarized study findings from maternal-fetal transfer of Contactin-associated protein-like 2, N-methyl-D-aspartate receptor and fetal brain autoantibodies associated with behavioral effects in animals and humans. We hypothesize that the maternal transfer of serum neuronal autoantibodies during or after birth could result (1) in the ignition of an autoimmune-mediated inflammation having neurodevelopmental consequences for their children (autoimmune-priming-attack hypothesis) and (2) has a potential impact on the later manifestation of psychiatric disorders. Through this narrative review, we propose a diagnostic pathway for the clinical diagnosis of a potentially autoimmune origin of psychiatric symptoms in children while considering recent guidelines.

Keyword(s): Adult (MeSH) ; Animals (MeSH) ; Autism Spectrum Disorder (MeSH) ; Autoantibodies (MeSH) ; Child (MeSH) ; Humans (MeSH) ; Obsessive-Compulsive Disorder (MeSH) ; Psychiatry (MeSH) ; Psychotic Disorders (MeSH)

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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