157730 20240918164037.0 pmc:PMC8515896 pmc 10.1016/j.celrep.2021.108871 doi pmid:33730583 pmid 2211-1247 ISSN 2639-1856 ISSN altmetric:101987296 altmetric DZNE-2021-01187 English 610 Baltruschat, Lothar P:(DE-2719)2810622 0 First author dzne Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation. [New York, NY] 2021 Elsevier article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1726662511_23571 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Drosophila Other Kenyon cell Other functional imaging Other functional plasticity Other memory consolidation Other microglomerulus Other mushroom body Other mushroom body calyx Other projection neuron Other structural plasticity Other Animals MeSH Axons: drug effects MeSH Axons: physiology MeSH Drosophila melanogaster: drug effects MeSH Drosophila melanogaster: physiology MeSH Drosophila melanogaster: ultrastructure MeSH Memory Consolidation: drug effects MeSH Memory Consolidation: physiology MeSH Memory, Long-Term: drug effects MeSH Mushroom Bodies: drug effects MeSH Mushroom Bodies: innervation MeSH Mushroom Bodies: ultrastructure MeSH Nerve Net: drug effects MeSH Nerve Net: physiology MeSH Nerve Net: ultrastructure MeSH Neuronal Plasticity: drug effects MeSH Odorants MeSH Oleic Acids: pharmacology MeSH Pheromones: pharmacology MeSH Synapses: drug effects MeSH Synapses: physiology MeSH Synapses: ultrastructure MeSH Prisco, Luigi P:(DE-2719)2812229 1 dzne Ranft, Philipp P:(DE-2719)2811269 2 dzne Lauritzen, J Scott 3 Fiala, André 4 Bock, Davi D 5 Tavosanis, Gaia P:(DE-2719)2810271 6 Last author dzne 10.1016/j.celrep.2021.108871 Vol. 34, no. 11, p. 108871 - PERI:(DE-600)2649101-1 11 108871 Cell reports 34 2021 2211-1247 https://www.sciencedirect.com/science/article/pii/S2211124721001856?via%3Dihub http://pub.dzne.de/record/157730/files/19426.pdf OpenAccess http://pub.dzne.de/record/157730/files/19426.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:157730 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810622 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2812229 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811269 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2810271 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 2021 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-02-03 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-02-03 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-02-03 Fees StatID:(DE-HGF)0700 StatID 2021-02-03 OpenAccess StatID:(DE-HGF)0510 StatID Article Processing Charges StatID:(DE-HGF)0561 StatID 2021-02-03 Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version) LIC:(DE-HGF)CCBYNCNDNV V:(DE-HGF) DOAJ 2021-02-03 JCR StatID:(DE-HGF)0100 StatID CELL REP : 2021 2022-11-17 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-17 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-17 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-01-26T13:08:57Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-01-26T13:08:57Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2021-01-26T13:08:57Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-17 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-17 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-17 IF >= 5 StatID:(DE-HGF)9905 StatID CELL REP : 2021 2022-11-17 I:(DE-2719)1013018 AG Tavosanis Dynamics of neuronal circuits 0 journal VDB I:(DE-2719)1013018 UNRESTRICTED FullTexts