17 Trabelsi, Khaled Ammar, Achraf Masmoudi, Liwa Boukhris, Omar Chtourou, Hamdi Bouaziz, Bassem Brach, Michael Bentlage, Ellen How, Daniella Ahmed, Mona Müller, Patrick Müller, Notger Hsouna, Hsen Elghoul, Yousri Romdhani, Mohamed Hammouda, Omar Paineiras-Domingos, Laisa Liane Braakman-Jansen, Annemarie Wrede, Christian Bastoni, Sofia Pernambuco, Carlos Soares Mataruna-Dos-Santos, Leonardo Jose Taheri, Morteza Irandoust, Khadijeh Bragazzi, Nicola L Strahler, Jana Washif, Jad Adrian Andreeva, Albina Bailey, Stephen J Acton, Jarred Mitchell, Emma Bott, Nicholas T Gargouri, Faiez Chaari, Lotfi Batatia, Hadj Khoshnami, Samira C Samara, Evangelia Zisi, Vasiliki Sankar, Parasanth Ahmed, Waseem N Ali, Gamal Mohamed Abdelkarim, Osama Jarraya, Mohamed Abed, Kais El Moalla, Wassim Souissi, Nafaa Aloui, Asma Souissi, Nizar Gemert-Pijnen, Lisette Van Riemann, Bryan L Riemann, Laurel Delhey, Jan Gómez-Raja, Jonathan Epstein, Monique Sanderman, Robbert Schulz, Sebastian Jerg, Achim Al-Horani, Ramzi Mansi, Taysir Dergaa, Ismail Jmail, Mohamed Barbosa, Fernando Ferreira-Santos, Fernando Šimunič, Boštjan Pišot, Rado Pišot, Saša Gaggioli, Andrea Steinacker, Jürgen Zmijewski, Piotr Apfelbacher, Christian Glenn, Jordan M Khacharem, Aïmen Clark, Cain C T Saad, Helmi Ben Chamari, Karim Driss, Tarak Hoekelmann, Anita On Behalf Of The Eclb-Covid Consortium AG Müller International journal of environmental research and public health International journal of environmental research and public health MDPI AG Basel 1660-4601 10.3390/ijerph18084329 English 4329 8 18 The COVID-19 lockdown could engender disruption to lifestyle behaviors, thus impairing mental wellbeing in the general population. This study investigated whether sociodemographic variables, changes in physical activity, and sleep quality from pre- to during lockdown were predictors of change in mental wellbeing in quarantined older adults.A 12-week international online survey was launched in 14 languages on 6 April 2020. Forty-one research institutions from Europe, Western-Asia, North-Africa, and the Americas, promoted the survey. The survey was presented in a differential format with questions related to responses 'pre' and 'during' the lockdown period. Participants responded to the Short Warwick-Edinburgh Mental Wellbeing Scale, the Pittsburgh Sleep Quality Index (PSQI) questionnaire, and the short form of the International Physical Activity Questionnaire.Replies from older adults (aged >55 years, n = 517), mainly from Europe (50.1%), Western-Asia (6.8%), America (30%), and North-Africa (9.3%) were analyzed. The COVID-19 lockdown led to significantly decreased mental wellbeing, sleep quality, and total physical activity energy expenditure levels (all p < 0.001). Regression analysis showed that the change in total PSQI score and total physical activity energy expenditure (F(2, 514) = 66.41 p < 0.001) were significant predictors of the decrease in mental wellbeing from pre- to during lockdown (p < 0.001, R2: 0.20).COVID-19 lockdown deleteriously affected physical activity and sleep patterns. Furthermore, change in the total PSQI score and total physical activity energy expenditure were significant predictors for the decrease in mental wellbeing. PUB:(DE-HGF)16, ; 0, ; Africa, Northern Aged Asia, Western COVID-19 Communicable Disease Control Europe Exercise Humans SARS-CoV-2 Sleep Surveys and Questionnaires aging home confinement lifestyle behaviors pandemic wellbeing Journal Article 2021 DZNE-2021-01230 2021 pmc:PMC8073845 pmid:33921852 https://pub.dzne.de/record/157773 https://doi.org/10.3390/ijerph18084329