162747 20230915092405.0 10.1038/s41419-021-04058-z doi pmid:34344867 pmid pmc:PMC8328816 pmc altmetric:111019540 altmetric DZNE-2021-01403 English 570 Mauriello, Alessandro 0000-0002-7351-5676 0 Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia. London [u.a.] 2021 Nature Publishing Group article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1655732808_9506 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote CC BY While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombocytopenia (VITT) with concurrent low platelets as well as capillary leak syndrome. In fact, the overall safety of the vaccine is highlighted by the low frequency of ADR considering that in UK, by the early June, 40 million first doses and 29 million second doses have been injected; nonetheless, 390 thrombotic events, including 71 fatal events have been reported. Interestingly, the cases reported low platelet counts with the presence of anti-platelet factor-4 (PF4) antibodies, indicating an abnormal clotting reaction. Here, out of three referred cases, we report a post-vaccine clinical case of fatal thrombosis with postmortem examination and whole exome sequencing (WES) analysis, whose pathogenesis appeared associated to a preexisting condition of thrombocytopenia due to myelodysplasia. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de COVID-19 Vaccines NLM Chemicals ChAdOx1 COVID-19 vaccine B5S3K2V0G8 NLM Chemicals ChAdOx1 nCoV-19 MeSH Bone Marrow: pathology MeSH COVID-19: prevention & control MeSH COVID-19 Vaccines: adverse effects MeSH Fatal Outcome MeSH Female MeSH Humans MeSH Lung: pathology MeSH Middle Aged MeSH Myelodysplastic Syndromes: complications MeSH Myelodysplastic Syndromes: diagnosis MeSH Myelodysplastic Syndromes: pathology MeSH SARS-CoV-2: immunology MeSH Thrombocytopenia: complications MeSH Thrombocytopenia: diagnosis MeSH Thrombocytopenia: pathology MeSH Thromboembolism: etiology MeSH Scimeca, Manuel 0000-0003-0585-1309 1 Amelio, Ivano 0000-0003-0739-325X 2 Massoud, Renato 0000-0001-7971-0715 3 Novelli, Antonio 0000-0002-5671-9220 4 Di Lorenzo, Francesca 0000-0001-8574-337X 5 Finocchiaro, Susanna 0000-0002-8684-4831 6 Cimino, Carolina 0000-0002-5793-9727 7 Telesca, Rossana 0000-0002-5365-7167 8 Chiocchi, Marcello 0000-0001-6041-4166 9 Sun, Qiang 0000-0001-8094-2214 10 Wang, Ying 0000-0002-2571-9367 11 Shi, Yufang 0000-0001-8964-319X 12 Novelli, Giuseppe 0000-0002-7781-602X 13 Melino, Gerry P:(DE-2719)9001390 14 Last author dzne 10.1038/s41419-021-04058-z Vol. 12, no. 8, p. 762 PERI:(DE-600)2541626-1 8 762 Cell death & disease 12 2021 2041-4889 OpenAccess http://pub.dzne.de/record/162747/files/DZNE-2021-01403.pdf OpenAccess pdfa http://pub.dzne.de/record/162747/files/DZNE-2021-01403.pdf?subformat=pdfa oai:pub.dzne.de:162747 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 14 P:(DE-2719)9001390 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 2021 Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ 2021-02-03 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-02-03 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-02-03 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-02-03 Fees StatID:(DE-HGF)0700 StatID 2021-02-03 OpenAccess StatID:(DE-HGF)0510 StatID Article Processing Charges StatID:(DE-HGF)0561 StatID 2021-02-03 JCR StatID:(DE-HGF)0100 StatID CELL DEATH DIS : 2021 2022-11-17 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-17 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-17 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-02-14T16:18:53Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-02-14T16:18:53Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2021-02-14T16:18:53Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-17 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-17 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-17 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-17 IF >= 5 StatID:(DE-HGF)9905 StatID CELL DEATH DIS : 2021 2022-11-17 I:(DE-2719)5000018 AG Nicotera Synaptic Connectivity and Neurodegeneration 0 journal VDB UNRESTRICTED I:(DE-2719)5000018 FullTexts