162762 20221128161201.0 10.1016/B978-0-12-819460-7.00270-X doi DZNE-2021-01418 Ermer, Veronika P:(DE-2719)9000864 0 First author dzne Cell Death | Cell Death by Apoptosis and Necrosis 2021 Elsevier Encyclopedia of Biological Chemistry III / Ermer, Veronika ; : Elsevier, 2021, ; ISBN: 9780128220405 ; doi:10.1016/B978-0-12-819460-7.00270-X 38-41 BOOK_CHAPTER ORCID Book Section 7 EndNote bookPart DRIVER INBOOK BibTeX Output Types/Book chapter DataCite Contribution to a book contb contb PUB:(DE-HGF)7 1653399053_26605 PUB:(DE-HGF) 5 Various genetically encoded programs involved in the signaling, initiation, and execution of cell death decide cells׳ fate during development and adult life. These programs can execute physiological cell death during development or tissue turnover, and are also involved in the inappropriate elimination of cells under pathological conditions. Because balanced cell turnover is essential for life, defects in cell elimination can also result in disease, the foremost example being cancer. In many circumstances, both physiological cell death and cell death in pathological settings have similar morphological and biochemical characteristics. Perhaps the best-characterized biochemical and morphological changes during a cell death program are those defined as apoptosis. Apoptosis is characterized by condensation and fragmentation of the nucleus with shrinkage of the cytoplasm and exposure of surface molecules that facilitate recognition of the dying cells by phagocytes. However, other types of cell death are present and are strictly regulated in vivo, including cell lysis/necrosis or autophagy. Imbalance in cellular calcium regulation has been involved in both apoptotic and nonapoptotic cell death. Calcium can be a signal for cell death or simply a downstream consequence of the activation of the death machinery. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef Book Nicotera, Pierluigi P:(DE-2719)2010732 1 dzne Stainbrook, Sarah C. 2 10.1016/B978-0-12-819460-7.00270-X VDB oai:pub.dzne.de:162762 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9000864 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2010732 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 2021 I:(DE-2719)5000018 AG Nicotera Synaptic Connectivity and Neurodegeneration 0 I:(DE-2719)1030000 Scientific board Scientific board 1 I:(DE-2719)1013003 AG Bano Aging and neurodegeneration 2 contb VDB I:(DE-2719)5000018 I:(DE-2719)1030000 I:(DE-2719)1013003 UNRESTRICTED