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@ARTICLE{Rosenbohm:162790,
      author       = {Rosenbohm, Angela and Del Tredici, Kelly and Braak, Heiko
                      and Huppertz, Hans-Jürgen and Ludolph, Albert and Müller,
                      Hans-Peter and Kassubek, Jan},
      title        = {{I}nvolvement of cortico-efferent tracts in flail arm
                      syndrome: a tract-of-interest-based {DTI} study.},
      journal      = {Journal of neurology},
      volume       = {269},
      number       = {5},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DZNE-2021-01445},
      pages        = {2619-2626},
      year         = {2022},
      note         = {ISSN 1432-1459 not unique: **2 hits**. (CC BY)},
      abstract     = {Flail arm syndrome is a restricted phenotype of motor
                      neuron disease that is characterized by progressive,
                      predominantly proximal weakness and atrophy of the upper
                      limbs.The study was designed to investigate specific white
                      matter alterations in diffusion tensor imaging (DTI) data
                      from flail arm syndrome patients using a hypothesis-guided
                      tract-of-interest-based approach to identify in vivo
                      microstructural changes according to a neuropathologically
                      defined amyotrophic lateral sclerosis (ALS)-related
                      pathology of the cortico-efferent tracts.DTI-based white
                      matter mapping was performed both by an unbiased voxel-wise
                      statistical comparison and by a hypothesis-guided tract-wise
                      analysis of fractional anisotropy (FA) maps according to the
                      neuropathological ALS-propagation pattern for 43 flail arm
                      syndrome patients vs 43 'classical' ALS patients vs 40
                      matched controls.The analysis of white matter integrity
                      demonstrated regional FA reductions for the flail arm
                      syndrome group predominantly along the CST. In the
                      tract-specific analysis according to the proposed sequential
                      cerebral pathology pattern of ALS, the flail arm syndrome
                      patients showed significant alterations of the specific
                      tract systems that were identical to 'classical' ALS if
                      compared to controls.The DTI study including the
                      tract-of-interest-based analysis showed a microstructural
                      involvement pattern in the brains of flail arm syndrome
                      patients, supporting the hypothesis that flail arm syndrome
                      is a phenotypical variant of ALS.},
      keywords     = {Amyotrophic Lateral Sclerosis: complications / Amyotrophic
                      Lateral Sclerosis: diagnostic imaging / Amyotrophic Lateral
                      Sclerosis: pathology / Anisotropy / Arm: diagnostic imaging
                      / Arm: pathology / Brain Mapping / Diffusion Tensor Imaging:
                      methods / Disease Progression / Humans / Image Processing,
                      Computer-Assisted: methods / Pyramidal Tracts / Vascular
                      Diseases / Amyotrophic lateral sclerosis (Other) / Diffusion
                      tensor imaging (Other) / Flail arm syndrome (Other) /
                      Magnetic resonance imaging (Other) / Motor neuron disease
                      (Other)},
      cin          = {Clinical Study Center Ulm},
      ddc          = {610},
      cid          = {I:(DE-2719)5000077},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9021061},
      pubmed       = {pmid:34676447},
      doi          = {10.1007/s00415-021-10854-6},
      url          = {https://pub.dzne.de/record/162790},
}