Home > Publications Database > Involvement of cortico-efferent tracts in flail arm syndrome: a tract-of-interest-based DTI study. > print

001     162790
005     20240227115126.0
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037 _ _ |a DZNE-2021-01445
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Rosenbohm, Angela
|b 0
245 _ _ |a Involvement of cortico-efferent tracts in flail arm syndrome: a tract-of-interest-based DTI study.
260 _ _ |a Berlin
|c 2022
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520 _ _ |a Flail arm syndrome is a restricted phenotype of motor neuron disease that is characterized by progressive, predominantly proximal weakness and atrophy of the upper limbs.The study was designed to investigate specific white matter alterations in diffusion tensor imaging (DTI) data from flail arm syndrome patients using a hypothesis-guided tract-of-interest-based approach to identify in vivo microstructural changes according to a neuropathologically defined amyotrophic lateral sclerosis (ALS)-related pathology of the cortico-efferent tracts.DTI-based white matter mapping was performed both by an unbiased voxel-wise statistical comparison and by a hypothesis-guided tract-wise analysis of fractional anisotropy (FA) maps according to the neuropathological ALS-propagation pattern for 43 flail arm syndrome patients vs 43 'classical' ALS patients vs 40 matched controls.The analysis of white matter integrity demonstrated regional FA reductions for the flail arm syndrome group predominantly along the CST. In the tract-specific analysis according to the proposed sequential cerebral pathology pattern of ALS, the flail arm syndrome patients showed significant alterations of the specific tract systems that were identical to 'classical' ALS if compared to controls.The DTI study including the tract-of-interest-based analysis showed a microstructural involvement pattern in the brains of flail arm syndrome patients, supporting the hypothesis that flail arm syndrome is a phenotypical variant of ALS.
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542 _ _ |i 2021-10-21
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650 _ 7 |a Amyotrophic lateral sclerosis
|2 Other
650 _ 7 |a Diffusion tensor imaging
|2 Other
650 _ 7 |a Flail arm syndrome
|2 Other
650 _ 7 |a Magnetic resonance imaging
|2 Other
650 _ 7 |a Motor neuron disease
|2 Other
650 _ 2 |a Amyotrophic Lateral Sclerosis: complications
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: diagnostic imaging
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: pathology
|2 MeSH
650 _ 2 |a Anisotropy
|2 MeSH
650 _ 2 |a Arm: diagnostic imaging
|2 MeSH
650 _ 2 |a Arm: pathology
|2 MeSH
650 _ 2 |a Brain Mapping
|2 MeSH
650 _ 2 |a Diffusion Tensor Imaging: methods
|2 MeSH
650 _ 2 |a Disease Progression
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Image Processing, Computer-Assisted: methods
|2 MeSH
650 _ 2 |a Pyramidal Tracts
|2 MeSH
650 _ 2 |a Vascular Diseases
|2 MeSH
700 1 _ |a Del Tredici, Kelly
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700 1 _ |a Braak, Heiko
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700 1 _ |a Huppertz, Hans-Jürgen
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700 1 _ |a Ludolph, Albert
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700 1 _ |a Müller, Hans-Peter
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700 1 _ |a Kassubek, Jan
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