Journal Article

DZNE-2021-01445

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Involvement of cortico-efferent tracts in flail arm syndrome: a tract-of-interest-based DTI study.

Rosenbohm, A. ; Del Tredici, K. ; Braak, H. ; Huppertz, H.-J. ; Ludolph, A.DZNE* ; Müller, H.-P. ; Kassubek, J. (Last author)DZNE*

2022
Springer Berlin

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Please use a persistent id in citations: doi:10.1007/s00415-021-10854-6

Abstract: Flail arm syndrome is a restricted phenotype of motor neuron disease that is characterized by progressive, predominantly proximal weakness and atrophy of the upper limbs.The study was designed to investigate specific white matter alterations in diffusion tensor imaging (DTI) data from flail arm syndrome patients using a hypothesis-guided tract-of-interest-based approach to identify in vivo microstructural changes according to a neuropathologically defined amyotrophic lateral sclerosis (ALS)-related pathology of the cortico-efferent tracts.DTI-based white matter mapping was performed both by an unbiased voxel-wise statistical comparison and by a hypothesis-guided tract-wise analysis of fractional anisotropy (FA) maps according to the neuropathological ALS-propagation pattern for 43 flail arm syndrome patients vs 43 'classical' ALS patients vs 40 matched controls.The analysis of white matter integrity demonstrated regional FA reductions for the flail arm syndrome group predominantly along the CST. In the tract-specific analysis according to the proposed sequential cerebral pathology pattern of ALS, the flail arm syndrome patients showed significant alterations of the specific tract systems that were identical to 'classical' ALS if compared to controls.The DTI study including the tract-of-interest-based analysis showed a microstructural involvement pattern in the brains of flail arm syndrome patients, supporting the hypothesis that flail arm syndrome is a phenotypical variant of ALS.

Keyword(s): Amyotrophic Lateral Sclerosis: complications (MeSH) ; Amyotrophic Lateral Sclerosis: diagnostic imaging (MeSH) ; Amyotrophic Lateral Sclerosis: pathology (MeSH) ; Anisotropy (MeSH) ; Arm: diagnostic imaging (MeSH) ; Arm: pathology (MeSH) ; Brain Mapping (MeSH) ; Diffusion Tensor Imaging: methods (MeSH) ; Disease Progression (MeSH) ; Humans (MeSH) ; Image Processing, Computer-Assisted: methods (MeSH) ; Pyramidal Tracts (MeSH) ; Vascular Diseases (MeSH) ; Amyotrophic lateral sclerosis ; Diffusion tensor imaging ; Flail arm syndrome ; Magnetic resonance imaging ; Motor neuron disease

Note: ISSN 1432-1459 not unique: **2 hits**. (CC BY)

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Contributing Institute(s):

1. Clinical Study Center Ulm (Clinical Study Center Ulm)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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