163766 20240305115237.0 pmc:PMC8968026 pmc 10.3389/fnsyn.2022.829354 doi altmetric:125634869 altmetric pmid:35368245 pmid DZNE-2022-00505 610 Gundelfinger, Eckart D P:(DE-2719)9000914 0 dzne Organization of Presynaptic Autophagy-Related Processes Lausanne 2022 Frontiers Research Foundation article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709568078_22643 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiological tasks. This applies in particular to the presynaptic part where neurotransmitter is released from synaptic vesicles, which in turn have to be recycled and refilled in a complex membrane trafficking cycle. Pathways to remove outdated and damaged proteins include the ubiquitin-proteasome system acting in the cytoplasm as well as membrane-associated endolysosomal and the autophagy systems. Here we focus on the latter systems and review what is known about the spatial organization of autophagy and endolysomal processes within the presynapse. We provide an inventory of which components of these degradative systems were found to be present in presynaptic boutons and where they might be anchored to the presynaptic apparatus. We identify three presynaptic structures reported to interact with known constituents of membrane-based protein-degradation pathways and therefore may serve as docking stations. These are (i) scaffolding proteins of the cytomatrix at the active zone, such as Bassoon or Clarinet, (ii) the endocytic machinery localized mainly at the peri-active zone, and (iii) synaptic vesicles. Finally, we sketch scenarios, how presynaptic autophagic cargos are tagged and recruited and which cellular mechanisms may govern membrane-associated protein turnover in the presynapse. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 1 Dataset connected to CrossRef, Journals: pub.dzne.de Karpova, Anna 1 Pielot, Rainer 2 Garner, Craig C. P:(DE-2719)2810922 3 dzne Kreutz, Michael R. P:(DE-2719)2811905 4 Last author dzne 10.3389/fnsyn.2022.829354 Vol. 14, p. 829354 PERI:(DE-600)2592086-8 829354 Frontiers in synaptic neuroscience 14 2022 1663-3563 http://pub.dzne.de/record/163766/files/DZNE-2022-00505.pdf OpenAccess http://pub.dzne.de/record/163766/files/DZNE-2022-00505.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:163766 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 0 P:(DE-2719)9000914 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2810922 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2811905 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 1 2022 Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ 2020-09-06 Fees StatID:(DE-HGF)0700 StatID 2020-09-06 OpenAccess StatID:(DE-HGF)0510 StatID Article Processing Charges StatID:(DE-HGF)0561 StatID 2020-09-06 JCR StatID:(DE-HGF)0100 StatID FRONT SYNAPTIC NEURO : 2021 2022-11-23 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-23 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-23 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-05-13T08:55:10Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-05-13T08:55:10Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2021-05-13T08:55:10Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-23 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-23 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-23 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-23 IF < 5 StatID:(DE-HGF)9900 StatID 2022-11-23 I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 0 I:(DE-2719)1810001 AG Garner Synaptopathy 1 journal VDB I:(DE-2719)5000006 I:(DE-2719)1810001 UNRESTRICTED FullTexts