164055 20241203165108.0 10.1038/s41418-022-01015-x doi pmid:35581387 pmid pmc:PMC9110941 pmc 1350-9047 ISSN 1476-5403 ISSN altmetric:128409180 altmetric DZNE-2022-00718 English 610 Li, Qing P:(DE-HGF)0 0 Immune response in COVID-19: what is next? London 2022 Macmillan article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1733229641_30590 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote (CC BY) The coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A better understanding of immunity and its regulation in response to SARS-CoV-2 infection is urgently needed. Based on the current literature, we review here the various virus mutations and the evolving disease manifestations along with the alterations of immune responses with specific focuses on the innate immune response, neutrophil extracellular traps, humoral immunity, and cellular immunity. Different types of vaccines were compared and analyzed based on their unique properties to elicit specific immunity. Various therapeutic strategies such as antibody, anti-viral medications and inflammation control were discussed. We predict that with the available and continuously emerging new technologies, more powerful vaccines and administration schedules, more effective medications and better public health measures, the COVID-19 pandemic will be under control in the near future. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de COVID-19 MeSH COVID-19 Vaccines MeSH Humans MeSH Immunity, Innate MeSH Pandemics: prevention & control MeSH SARS-CoV-2 MeSH Wang, Ying 0000-0002-2571-9367 1 Sun, Qiang 2 Knopf, Jasmin 0000-0003-2922-9370 3 Herrmann, Martin 0000-0002-0258-2484 4 Lin, Liangyu 0000-0003-4312-8955 5 Jiang, Jingting 0000-0002-3128-9762 6 Shao, Changshun 0000-0003-2618-9342 7 Li, Peishan 0000-0002-6881-396X 8 He, Xiaozhou 9 Hua, Fei 10 Niu, Zubiao 11 Ma, Chaobing 12 Zhu, Yichao 13 Ippolito, Giuseppe 14 Piacentini, Mauro 15 Estaquier, Jerome 0000-0002-9432-8044 16 Melino, Sonia 17 Weiss, Felix Daniel 0000-0003-0228-5081 18 Andreano, Emanuele 0000-0003-0088-5788 19 Latz, Eicke P:(DE-2719)2000062 20 Schultze, Joachim P:(DE-2719)2811660 21 Rappuoli, Rino 22 Mantovani, Alberto 0000-0001-5578-236X 23 Mak, Tak Wah 24 Melino, Gerry P:(DE-2719)9001390 25 Shi, Yufang 0000-0001-8964-319X 26 10.1038/s41418-022-01015-x PERI:(DE-600)1496681-5 1107-1122 Cell death and differentiation 29 2022 1350-9047 http://pub.dzne.de/record/164055/files/DZNE-2022-00718.pdf OpenAccess http://pub.dzne.de/record/164055/files/DZNE-2022-00718.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:164055 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 20 P:(DE-2719)2000062 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 21 P:(DE-2719)2811660 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 25 P:(DE-2719)9001390 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 1 2022 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-30 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-01-26 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-30 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-01-26 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-30 JCR StatID:(DE-HGF)0100 StatID CELL DEATH DIFFER : 2021 2022-11-30 IF >= 10 StatID:(DE-HGF)9910 StatID CELL DEATH DIFFER : 2021 2022-11-30 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-01-26 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-30 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-30 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-30 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-30 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-30 I:(DE-2719)1013024 AG Latz Innate Immunity in Neurodegeneration 0 I:(DE-2719)5000018 AG Nicotera Synaptic Connectivity and Neurodegeneration 1 I:(DE-2719)1013038 AG Schultze Clinical Single Cell Omics (CSCO) / Systems Medicine 2 journal VDB I:(DE-2719)1013024 I:(DE-2719)5000018 I:(DE-2719)1013038 UNRESTRICTED FullTexts