164110 20241203165109.0 2001-8525 ISSN pmc:PMC9386332 pmc 10.1183/13993003.02057-2021 doi pmid:35086829 pmid 0903-1936 ISSN 1399-3003 ISSN altmetric:121782786 altmetric DZNE-2022-00773 English 610 Luecken, Malte D 0 The discovAIR project: a roadmap towards the Human Lung Cell Atlas. Lausanne 2022 ERS article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1733217633_30592 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote CC BY-NC: https://creativecommons.org/licenses/by-nc/4.0/ The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The lung biological network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and the cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework program. DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Humans MeSH Lung MeSH Lung Diseases MeSH Proteomics MeSH Thorax MeSH EXP:(DE-2719)PRECISE-20190321 EXP:(DE-2719)PRECISE-20190321 Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn 0 Zaragosi, Laure-Emmanuelle 0000-0001-6747-7928 1 Madissoon, Elo 2 Sikkema, Lisa 0000-0001-9686-6295 3 Firsova, Alexandra B 4 De Domenico, Elena P:(DE-2719)9000846 5 dzne Kümmerle, Louis 6 Saglam, Adem P:(DE-2719)2812564 7 dzne Berg, Marijn 8 Gay, Aurore C A 9 Schniering, Janine 0000-0001-7869-4936 10 Mayr, Christoph H 11 Abalo, Xesús M 0000-0002-1643-0705 12 Larsson, Ludvig 13 Sountoulidis, Alexandros 14 Teichmann, Sarah 15 van Eunen, Karen 16 Koppelman, Gerard H 0000-0001-8567-3252 17 Saeb-Parsy, Kourosh 18 Leroy, Sylvie 19 Powell, Pippa 20 Sarkans, Ugis 21 Timens, Wim 0000-0002-4146-6363 22 Lundeberg, Joakim 23 van den Berge, Maarten 24 Nilsson, Mats 25 Horváth, Peter 26 Denning, Jessica 27 Papatheodorou, Irene 28 Schultze, Joachim P:(DE-2719)2811660 29 dzne Schiller, Herbert B 30 Barbry, Pascal 0000-0001-9632-6483 31 Petoukhov, Ilya 32 Misharin, Alexander V 33 Adcock, Ian 0000-0003-2101-8843 34 von Papen, Michael 35 Theis, Fabian J 36 Samakovlis, Christos 37 Meyer, Kerstin B 38 Nawijn, Martijn C 0000-0003-3372-6521 39 10.1183/13993003.02057-2021 p. 2102057 - PERI:(DE-600)1499101-9 2 2102057 The European respiratory journal 60 2022 0903-1936 http://pub.dzne.de/record/164110/files/DZNE-2022-00773.pdf OpenAccess http://pub.dzne.de/record/164110/files/DZNE-2022-00773.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:164110 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)9000846 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2812564 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 29 P:(DE-2719)2811660 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 2022 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-05 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-01-28 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-05 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-01-28 JCR StatID:(DE-HGF)0100 StatID EUR RESPIR J : 2021 2022-11-05 IF >= 30 StatID:(DE-HGF)9930 StatID EUR RESPIR J : 2021 2022-11-05 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-01-28 Creative Commons Attribution-NonCommercial CC BY-NC 4.0 LIC:(DE-HGF)CCBYNC4 HGFVOC DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-05 OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-05 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-05 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2022-11-05 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-05 I:(DE-2719)1013031 PRECISE Platform for Single Cell Genomics and Epigenomics 0 I:(DE-2719)1013038 AG Schultze Clinical Single Cell Omics (CSCO) / Systems Medicine 1 journal VDB I:(DE-2719)1013031 I:(DE-2719)1013038 UNRESTRICTED FullTexts