165105 20230915090605.0 10.1371/journal.ppat.1010747 doi pmid:35960762 pmid pmc:PMC9401167 pmc 1553-7366 ISSN 1553-7374 ISSN altmetric:134032652 altmetric DZNE-2022-01414 English 610 Kaczmarczyk, Lech P:(DE-2719)2810486 0 First author Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice. Lawrence, Kan. 2022 PLoS article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1670592859_11874 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote CC BY: https://creativecommons.org/licenses/by/4.0/ Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific cell types and brain regions. Using the RiboTag method in mice, translational responses of five neural subtypes to acquired prion disease (PrD) were measured. Pre-onset and disease onset timepoints were chosen based on longitudinal electroencephalography (EEG) that revealed a gradual increase in theta power between 10- and 18-weeks after prion injection, resembling a clinical feature of human PrD. At disease onset, marked by significantly increased theta power and histopathological lesions, mice had pronounced translatome changes in all five cell types despite appearing normal. Remarkably, at a pre-onset stage, prior to EEG and neuropathological changes, we found that 1) translatomes of astrocytes indicated reduced synthesis of ribosomal and mitochondrial components, 2) glutamatergic neurons showed increased expression of cytoskeletal genes, and 3) GABAergic neurons revealed reduced expression of circadian rhythm genes. These data demonstrate that early translatome responses to neurodegeneration emerge prior to conventional markers of disease and are cell type-specific. Therapeutic strategies may need to target multiple pathways in specific populations of cells, early in disease. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Prions NLM Chemicals Animals MeSH Brain: pathology MeSH Electroencephalography MeSH Humans MeSH Mice MeSH Neurons: metabolism MeSH Prion Diseases: pathology MeSH Prions: metabolism MeSH Schleif, Melvin P:(DE-2719)2810344 1 Dittrich, Lars P:(DE-2719)2811120 2 Williams, Rhiannan H 3 Koderman, Maruša 4 Bansal, Vikas P:(DE-2719)2812055 5 Rajput, Ashish P:(DE-2719)2811012 6 Schulte, Theresa P:(DE-2719)2810775 7 Jonson, Maria 8 Krost, Clemens P:(DE-2719)2810527 9 Testaquadra, Fabio J P:(DE-2719)9002378 10 dzne Bonn, Stefan P:(DE-2719)2810547 11 Jackson, Walker Scot P:(DE-2719)2810253 12 Last author 10.1371/journal.ppat.1010747 Vol. 18, no. 8, p. e1010747 - PERI:(DE-600)2205412-1 8 e1010747 PLoS pathogens 18 2022 1553-7366 http://pub.dzne.de/record/165105/files/DZNE-2022-01414.pdf OpenAccess http://pub.dzne.de/record/165105/files/DZNE-2022-01414.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:165105 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810486 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810344 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811120 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2812055 External Institute I:(DE-HGF)0 Extern 6 P:(DE-2719)2811012 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2810775 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2810527 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 10 P:(DE-2719)9002378 External Institute I:(DE-HGF)0 Extern 11 P:(DE-2719)2810547 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 12 P:(DE-2719)2810253 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 1 2022 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-01-27 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-01-27 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC OpenAccess StatID:(DE-HGF)0510 StatID Article Processing Charges StatID:(DE-HGF)0561 StatID 2021-01-27 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-01-27 Fees StatID:(DE-HGF)0700 StatID 2021-01-27 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-25 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-25 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2022-04-12T10:19:57Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2022-04-12T10:19:57Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2022-04-12T10:19:57Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-25 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-25 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-25 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-25 JCR StatID:(DE-HGF)0100 StatID PLOS PATHOG : 2021 2022-11-25 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-25 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-25 IF >= 5 StatID:(DE-HGF)9905 StatID PLOS PATHOG : 2021 2022-11-25 I:(DE-2719)1013019 AG Jackson Selective Vulnerability of Neurodegenerative Diseases 0 I:(DE-2719)1210002 AG Heutink 1 Genome Biology of Neurodegenerative Diseases 1 I:(DE-2719)1013020 AG Petzold Neurovascular Diseases 2 journal VDB I:(DE-2719)1013019 I:(DE-2719)1210002 I:(DE-2719)1013020 UNRESTRICTED FullTexts