165107 20230915090605.0 10.3389/fncel.2022.788150 doi pmid:35910248 pmid pmc:PMC9329528 pmc altmetric:133170675 altmetric DZNE-2022-01416 English 610 Polyakova, Maryna 0 Increased Serum NSE and S100B Indicate Neuronal and Glial Alterations in Subjects Under 71 Years With Mild Neurocognitive Disorder/Mild Cognitive Impairment. Lausanne 2022 Frontiers Research Foundation article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1664540963_12113 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Mild cognitive impairment (MCI) is considered a pre-stage of different dementia syndromes. Despite diagnostic criteria refined by DSM-5 and a new term for MCI - 'mild neurocognitive disorder' (mild NCD) - this diagnosis is still based on clinical criteria.To link mild NCD to the underlying pathophysiology we assessed the degree of white matter hyperintensities (WMH) in the brain and peripheral biomarkers for neuronal integrity (neuron-specific enolase, NSE), plasticity (brain-derived neurotrophic factor, BDNF), and glial function (S100B) in 158 community-dwelling subjects with mild NCD and 82 healthy controls. All participants (63-79 years old) were selected from the Leipzig-population-based study of adults (LIFE).Serum S100B levels were increased in mild NCD in comparison to controls (p = 0.007). Serum NSE levels were also increased but remained non-significant after Bonferroni-Holm correction (p = 0.04). Furthermore, age by group interaction was significant for S100B. In an age-stratified sub-analysis, NSE and S100B were higher in younger subjects with mild NCD below 71 years of age. Some effects were inconsistent after controlling for potentially confounding factors. The discriminatory power of the two biomarkers NSE and S100B was insufficient to establish a pathologic threshold for mild NCD. In subjects with mild NCD, WMH load correlated with serum NSE levels (r = 0.20, p = 0.01), independently of age.Our findings might indicate the presence of neuronal (NSE) and glial (S100B) injury in mild NCD. Future studies need to investigate whether younger subjects with mild NCD with increased biomarker levels are at risk of developing major NCD. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de BDNF Other Brain-Derived Neurotrophic Factor Other NSE Other S100B Other mild cognitive impairment Other neuron-specific enolase Other white matter hyperintensities Other Mueller, Karsten 1 Arelin, Katrin 2 Lampe, Leonie 3 Rodriguez, Francisca S P:(DE-2719)9000725 4 dzne Luck, Tobias 5 Kratzsch, Jürgen 6 Hoffmann, Karl-Titus 7 Riedel-Heller, Steffi 8 Villringer, Arno 9 Schoenknecht, Peter 10 Schroeter, Matthias L 11 10.3389/fncel.2022.788150 Vol. 16, p. 788150 PERI:(DE-600)2452963-1 788150 Frontiers in cellular neuroscience 16 2022 1662-5102 http://pub.dzne.de/record/165107/files/DZNE-2022-01416.pdf OpenAccess http://pub.dzne.de/record/165107/files/DZNE-2022-01416.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:165107 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9000725 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2022 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-05-04 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-05-04 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-05-04 Fees StatID:(DE-HGF)0700 StatID 2021-05-04 OpenAccess StatID:(DE-HGF)0510 StatID Article Processing Charges StatID:(DE-HGF)0561 StatID 2021-05-04 JCR StatID:(DE-HGF)0100 StatID FRONT CELL NEUROSCI : 2021 2022-11-25 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-25 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-25 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-05-13T10:30:24Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-05-13T10:30:24Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2021-05-13T10:30:24Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-25 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-25 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-25 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2022-11-25 IF >= 5 StatID:(DE-HGF)9905 StatID FRONT CELL NEUROSCI : 2021 2022-11-25 I:(DE-2719)1713001 AG Rodriguez-Muela Selective Neuronal Vulnerability in Neurodegenerative Diseases 0 journal VDB UNRESTRICTED I:(DE-2719)1713001 FullTexts