165242 20240306115248.0 pmc:PMC9763100 pmc 10.1038/s41380-022-01761-x doi pmid:36117208 pmid 1359-4184 ISSN 1476-5578 ISSN altmetric:136074249 altmetric DZNE-2022-01535 English 610 Liebe, Thomas 0 In vivo tractography of human locus coeruleus-relation to 7T resting state fMRI, psychological measures and single subject validity. London 2022 Macmillan article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709647370_29111 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote CC BY: https://creativecommons.org/licenses/by/4.0/ The locus coeruleus (LC) in the brainstem as the main regulator of brain noradrenaline gains increasing attention because of its involvement in neurologic and psychiatric diseases and its relevance in general to brain function. In this study, we created a structural connectome of the LC nerve fibers based on in vivo MRI tractography to gain an understanding into LC connectivity and its impact on LC-related psychological measures. We combined our structural results with ultra-high field resting-state functional MRI to learn about the relationship between in vivo LC structural and functional connections. Importantly, we reveal that LC brain fibers are strongly associated with psychological measures of anxiety and alertness indicating that LC-noradrenergic connectivity may have an important role on brain function. Lastly, since we analyzed all our data in subject-specific space, we point out the potential of structural LC connectivity to reveal individual characteristics of LC-noradrenergic function on the single-subject level. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Humans MeSH Locus Coeruleus MeSH Magnetic Resonance Imaging: methods MeSH Brain: physiology MeSH Connectome: methods MeSH Attention MeSH Kaufmann, Jörn 1 Hämmerer, Dorothea P:(DE-2719)2811927 2 dzne Betts, Matthew P:(DE-2719)2810555 3 dzne Walter, Martin 0000-0001-7857-4483 4 10.1038/s41380-022-01761-x PERI:(DE-600)1502531-7 12 4984-4993 Molecular psychiatry 27 2022 1359-4184 http://pub.dzne.de/record/165242/files/DZNE-2022-01535.pdf OpenAccess http://pub.dzne.de/record/165242/files/DZNE-2022-01535.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:165242 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811927 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2810555 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2022 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-01-28 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-01-28 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-01-28 OpenAccess StatID:(DE-HGF)0510 StatID Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-19 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-19 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-19 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-19 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-19 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-19 JCR StatID:(DE-HGF)0100 StatID MOL PSYCHIATR : 2021 2022-11-19 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-19 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-19 IF >= 10 StatID:(DE-HGF)9910 StatID MOL PSYCHIATR : 2021 2022-11-19 I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 0 journal VDB I:(DE-2719)5000006 UNRESTRICTED FullTexts