165607 20250127111033.0 10.1016/j.mcn.2022.103795 doi pmid:36436725 pmid 1044-7431 ISSN 1095-9327 ISSN DZNE-2022-01740 English 610 Garner, Craig P:(DE-2719)2810922 0 First author dzne Synaptic logistics: The presynaptic scaffold protein Piccolo a nodal point tuning synaptic vesicle recycling, maintenance and integrity. San Diego, Calif. 2023 Elsevier article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1708514204_22067 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Properly working synapses are one important guarantor for a functional and healthy brain. They are small, densely packed structures, where information is transmitted through the release of neurotransmitters from synaptic vesicles (SVs). The latter cycle within the presynaptic terminal as they first fuse with the plasma membrane to deliver their neurotransmitter, and afterwards become recycled and prepared for a new release event. The synapse is an autonomous structure functioning mostly independent of the neuronal soma. Dysfunction in synaptic processes associated with local insults or genetic abnormalities can directly compromise synapse function and integrity and subsequently lead to the onset of neurodegenerative diseases. Therefore, measures need to be in place counteracting these threats for instance through the continuous replacement of old and damaged SV proteins. Interestingly recent studies show that the presynaptic scaffolding protein Piccolo contributes to health, function and integrity of synapses, as it mediates the delivery of synaptic proteins from the trans-Golgi network (TGN) towards synapses, as well as the local recycling and turnover of SV proteins within synaptic terminals. It can fulfill these various tasks through its multi-domain structure and ability to interact with numerous binding partners. In addition, Piccolo has recently been linked with the early onset neurodegenerative disease Pontocerebellar Hypoplasia Type 3 (PCH3) further underlying its importance for neuronal health. In this review, we will focus on Piccolo's contributions to synapse function, health and integrity and make a connection how those may contribute to the disease pattern of PCH3. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Neurodegenerative disease Other Pontocerebellar hypoplasia Other Presynaptic scaffolding protein piccolo Other SV recycling Other Synapse health Other Synapse intergrity Other Olivopontocerebellar Atrophies MeSH Humans MeSH Synaptic Vesicles: metabolism MeSH Neurodegenerative Diseases: metabolism MeSH Synapses: metabolism MeSH Presynaptic Terminals: metabolism MeSH Biological Transport MeSH Ackermann, Frauke P:(DE-2719)2810967 1 Last author dzne 10.1016/j.mcn.2022.103795 p. 103795 - PERI:(DE-600)1471177-1 103795 Molecular and cellular neuroscience 124 2023 1044-7431 http://pub.dzne.de/record/165607/files/DZNE-2022-01740_Restricted.pdf http://pub.dzne.de/record/165607/files/DZNE-2022-01740_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:165607 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810922 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810967 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 2023 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2021-01-27 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2021-01-27 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2021-01-27 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2022-11-18 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2022-11-18 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2022-11-18 Nationallizenz StatID:(DE-HGF)0420 StatID 2023-08-22 ger JCR StatID:(DE-HGF)0100 StatID MOL CELL NEUROSCI : 2022 2023-08-22 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-22 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-22 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-08-22 Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-08-22 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-22 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-08-22 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-22 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2023-08-22 IF < 5 StatID:(DE-HGF)9900 StatID 2023-08-22 I:(DE-2719)1810001 AG Garner Synaptopathy 0 I:(DE-2719)1813004 AG Ackermann Astrocyte - Synapse Interactions 1 journal VDB I:(DE-2719)1810001 I:(DE-2719)1813004 UNRESTRICTED