169151 20250127111030.0 pmc:PMC9849315 pmc 10.1007/s00401-022-02524-2 doi pmid:36512061 pmid 0001-6322 ISSN 1432-0533 ISSN altmetric:140122548 altmetric DZNE-2023-00030 English 610 Nelson, Peter T 0 LATE-NC staging in routine neuropathologic diagnosis: an update. Heidelberg 2023 Springer article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1718027234_5321 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and nomenclature have proven useful for autopsy practice and dementia research. However, some issues remain unresolved, such as cases with unusual features that do not fit with current diagnostic categories. The goal of this report is to update the neuropathologic criteria for the diagnosis and staging of LATE-NC, based primarily on published data. We provide practical suggestions about how to integrate available genetic information and comorbid pathologies [e.g., Alzheimer's disease neuropathologic changes (ADNC) and Lewy body disease]. We also describe recent research findings that have enabled more precise guidance on how to differentiate LATE-NC from other subtypes of TDP-43 pathology [e.g., frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)], and how to render diagnoses in unusual situations in which TDP-43 pathology does not follow the staging scheme proposed in 2019. Specific recommendations are also made on when not to apply this diagnostic term based on current knowledge. Neuroanatomical regions of interest in LATE-NC are described in detail and the implications for TDP-43 immunohistochemical results are specified more precisely. We also highlight questions that remain unresolved and areas needing additional study. In summary, the current work lays out a number of recommendations to improve the precision of LATE-NC staging based on published reports and diagnostic experience. 352 - Disease Mechanisms (POF4-352) G:(DE-HGF)POF4-352 POF4-352 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de DNA-Binding Proteins NLM Chemicals Aging Other Dementia Other FTD Other Hippocampal sclerosis Other NCI Other Neuroanatomy Other Processes Other Stages Other TDP-43 Other Dementia MeSH Humans MeSH Alzheimer Disease: pathology MeSH Frontotemporal Dementia: pathology MeSH Amyotrophic Lateral Sclerosis: pathology MeSH DNA-Binding Proteins: genetics MeSH TDP-43 Proteinopathies MeSH Lee, Edward B 1 Cykowski, Matthew D 2 Alafuzoff, Irina 3 Arfanakis, Konstantinos 4 Attems, Johannes 5 Brayne, Carol 6 Corrada, Maria M 7 Dugger, Brittany N 8 Flanagan, Margaret E 9 Ghetti, Bernardino 10 Grinberg, Lea T 11 Grossman, Murray 12 Grothe, Michel J P:(DE-2719)2810708 13 dzne Halliday, Glenda M 14 Hasegawa, Masato 15 Hokkanen, Suvi R K P:(DE-2719)9000134 16 dzne Hunter, Sally 17 Jellinger, Kurt 18 Kawas, Claudia H 19 Keene, C Dirk 20 Kouri, Naomi 21 Kovacs, Gabor G 22 Leverenz, James B 23 Latimer, Caitlin S 24 Mackenzie, Ian R P:(DE-2719)9000939 25 dzne Mao, Qinwen 26 McAleese, Kirsty E 27 Merrick, Richard 28 Montine, Thomas J 29 Murray, Melissa E 30 Myllykangas, Liisa 31 Nag, Sukriti 32 Neltner, Janna H 33 Newell, Kathy L 34 Rissman, Robert A 35 Saito, Yuko 36 Sajjadi, S Ahmad 37 Schwetye, Katherine E 38 Teich, Andrew F 39 Thal, Dietmar R 40 Tomé, Sandra O 41 Troncoso, Juan C 42 Wang, Shih-Hsiu J 43 White, Charles L 44 Wisniewski, Thomas 45 Yang, Hyun-Sik 46 Schneider, Julie A 47 Dickson, Dennis W 48 Neumann, Manuela P:(DE-2719)2810592 49 Last author dzne 10.1007/s00401-022-02524-2 Vol. 145, no. 2, p. 159 - 173 PERI:(DE-600)1458410-4 2 159 - 173 Acta neuropathologica 145 2023 0001-6322 http://pub.dzne.de/record/169151/files/DZNE-2023-00030%20SUP.pdf http://pub.dzne.de/record/169151/files/DZNE-2023-00030%20SUP.pdf?subformat=pdfa pdfa http://pub.dzne.de/record/169151/files/DZNE-2023-00030.pdf OpenAccess http://pub.dzne.de/record/169151/files/DZNE-2023-00030.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:169151 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 13 P:(DE-2719)2810708 External Institute I:(DE-HGF)0 Extern 16 P:(DE-2719)9000134 External Institute I:(DE-HGF)0 Extern 25 P:(DE-2719)9000939 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 49 P:(DE-2719)2810592 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-352 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Mechanisms 0 2023 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-10-21 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-10-21 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-10-21 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2022-11-29 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-10-21 JCR StatID:(DE-HGF)0100 StatID ACTA NEUROPATHOL : 2022 2023-10-21 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2023-10-21 IF >= 10 StatID:(DE-HGF)9910 StatID ACTA NEUROPATHOL : 2022 2023-10-21 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2022-11-29 DEAL Springer StatID:(DE-HGF)3002 StatID 2022-11-29 ger OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-10-21 Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-10-21 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2022-11-29 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-10-21 I:(DE-2719)1210003 AG Neumann Molecular Neuropathology of Neurodegenerative Diseases 0 journal VDB I:(DE-2719)1210003 UNRESTRICTED FullTexts