194973 20240306115250.0 pmc:PMC10182252 pmc 10.1002/alz.12937 doi pmid:36642985 pmid 1552-5260 ISSN 1552-5279 ISSN altmetric:141358327 altmetric DZNE-2023-00160 English 610 Ehrenberg, Alexander J 0 Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART. Hoboken, NJ 2023 Wiley article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709646971_29111 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic tone, and homeostasis. Tau-associated NSS degeneration occurs early in Alzheimer's disease (AD) pathogenesis, long before the emergence of pathognomonic memory dysfunction and cortical lesions. Accumulating evidence supports the role of NSS dysfunction and degeneration in the behavioral and neuropsychiatric manifestations featured early in AD. Experimental studies even suggest that AD-associated NSS degeneration drives brain neuroinflammatory status and contributes to disease progression, including the exacerbation of cortical lesions. Given the important pathophysiologic and etiologic roles that involve the NSS in early AD stages, there is an urgent need to expand our understanding of the mechanisms underlying NSS vulnerability and more precisely detail the clinical progression of NSS changes in AD. Here, the NSS Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment highlights knowledge gaps about NSS within AD and provides recommendations for priorities specific to clinical research, biomarker development, modeling, and intervention. HIGHLIGHTS: Neuromodulatory nuclei degenerate in early Alzheimer's disease pathological stages. Alzheimer's pathophysiology is exacerbated by neuromodulatory nuclei degeneration. Neuromodulatory nuclei degeneration drives neuropsychiatric symptoms in dementia. Biomarkers of neuromodulatory integrity would be value-creating for dementia care. Neuromodulatory nuclei present strategic prospects for disease-modifying therapies. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Biomarkers NLM Chemicals Humans MeSH Alzheimer Disease: pathology MeSH Brain: pathology MeSH Biomarkers MeSH Disease Progression MeSH Kelberman, Michael A 1 Liu, Kathy Y P:(DE-HGF)0 2 Dahl, Martin J 3 Weinshenker, David 4 Falgàs, Neus 5 Dutt, Shubir 6 Mather, Mara 7 Ludwig, Mareike P:(DE-2719)9002575 8 dzne Betts, Matthew J P:(DE-2719)2810555 9 Winer, Joseph R 10 Teipel, Stefan P:(DE-2719)2000026 11 Weigand, Alexandra J 12 Eschenko, Oxana 13 Hämmerer, Dorothea P:(DE-2719)2811927 14 Leiman Algranati, Marina P:(DE-2719)9001927 15 Counts, Scott E 16 Shine, James M 17 Robertson, Ian H 18 Levey, Allan I 19 Lancini, Elisa P:(DE-2719)9002565 20 dzne Son, Gowoon 21 Schneider, Chrisoph 22 Egroo, Maxime Van 23 Liguori, Claudio 24 Wang, Qin P:(DE-HGF)0 25 Vazey, Elena M 26 Rodriguez-Porcel, Federico 27 Haag, Lena P:(DE-2719)9002566 28 dzne Bondi, Mark W 29 Vanneste, Sven 30 Freeze, Whitney M 31 Yi, Yeo-Jin P:(DE-2719)9002257 32 Maldinov, Mihovil 33 Gatchel, Jennifer 34 Satpati, Abhijit 35 Babiloni, Claudio 36 Kremen, William S 37 Howard, Robert 38 Jacobs, Heidi I L 39 Grinberg, Lea T 40 10.1002/alz.12937 p. alz.12937 PERI:(DE-600)2201940-6 5 2182-2196 Alzheimer's and dementia 19 2023 1552-5260 http://pub.dzne.de/record/194973/files/DZNE-2023-00160%20SUP.doc http://pub.dzne.de/record/194973/files/DZNE-2023-00160%20SUP.docx http://pub.dzne.de/record/194973/files/DZNE-2023-00160%20SUP.odt http://pub.dzne.de/record/194973/files/DZNE-2023-00160%20SUP.pdf http://pub.dzne.de/record/194973/files/DZNE-2023-00160.pdf OpenAccess http://pub.dzne.de/record/194973/files/DZNE-2023-00160.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:194973 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 8 P:(DE-2719)9002575 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2810555 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 11 P:(DE-2719)2000026 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 14 P:(DE-2719)2811927 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 15 P:(DE-2719)9001927 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 20 P:(DE-2719)9002565 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 28 P:(DE-2719)9002566 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 32 P:(DE-2719)9002257 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2023 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2022-11-11 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DEAL Wiley StatID:(DE-HGF)3001 StatID 2022-11-11 ger WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2022-11-11 OpenAccess StatID:(DE-HGF)0510 StatID JCR StatID:(DE-HGF)0100 StatID ALZHEIMERS DEMENT : 2022 2023-10-25 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-10-25 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-10-25 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-10-25 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-10-25 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2023-10-25 IF >= 10 StatID:(DE-HGF)9910 StatID ALZHEIMERS DEMENT : 2022 2023-10-25 I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 0 I:(DE-2719)1510100 AG Teipel Clinical Dementia Research (Rostock /Greifswald) 1 journal VDB I:(DE-2719)5000006 I:(DE-2719)1510100 UNRESTRICTED FullTexts