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000257583 1001_ $$0P:(DE-2719)2812856$$aChatterjee, Madhurima$$b0$$eFirst author$$udzne
000257583 245__ $$aC1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: A multi-cohort proteomics and immuno-assay validation study.
000257583 260__ $$aHoboken, NJ$$bWiley$$c2023
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000257583 520__ $$aExtracellular vesicles (EVs) may propagate and modulate Alzheimer's disease (AD) pathology. We aimed to comprehensively characterize the proteome of cerebrospinal fluid (CSF) EVs to identify proteins and pathways altered in AD.CSF EVs were isolated by ultracentrifugation (Cohort 1) or Vn96 peptide (Cohort 2) from non-neurodegenerative controls (n = 15, 16) and AD patients (n = 22, 20, respectively). EVs were subjected to untargeted quantitative mass spectrometry-based proteomics. Results were validated by enzyme-linked immunosorbent assay (ELISA) in Cohorts 3 and 4, consisting of controls (n = 16, n = 43, (Cohort3, Cohort4)), and patients with AD (n = 24, n = 100).We found > 30 differentially expressed proteins in AD CSF EVs involved in immune-regulation. Increase of C1q levels in AD compared to non-demented controls was validated by ELISA (∼ 1.5 fold, p (Cohort 3) = 0.03, p (Cohort 4) = 0.005).EVs may be utilized as a potential biomarker and may play a so far unprecedented role in immune-regulation in AD.
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000257583 650_7 $$080295-33-6$$2NLM Chemicals$$aComplement C1q
000257583 650_7 $$2Other$$aAlzheimer's disease (AD)
000257583 650_7 $$2Other$$abiomarker
000257583 650_7 $$2Other$$acerebrospinal fluid (CSF)
000257583 650_7 $$2Other$$acomplement
000257583 650_7 $$2Other$$aextracellular vesicles
000257583 650_7 $$2Other$$aimmune system
000257583 650_7 $$2Other$$amild cognitive impairment (MCI)
000257583 650_7 $$2Other$$aproteomics
000257583 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000257583 650_7 $$2NLM Chemicals$$aPeptide Fragments
000257583 650_7 $$2NLM Chemicals$$aBiomarkers
000257583 650_7 $$2NLM Chemicals$$atau Proteins
000257583 650_2 $$2MeSH$$aHumans
000257583 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000257583 650_2 $$2MeSH$$aComplement C1q
000257583 650_2 $$2MeSH$$aProteomics
000257583 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000257583 650_2 $$2MeSH$$aPeptide Fragments: cerebrospinal fluid
000257583 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000257583 650_2 $$2MeSH$$aExtracellular Vesicles: metabolism
000257583 650_2 $$2MeSH$$atau Proteins: cerebrospinal fluid
000257583 650_2 $$2MeSH$$aCognitive Dysfunction: cerebrospinal fluid
000257583 7001_ $$0P:(DE-2719)9002048$$aÖzdemir, Selcuk$$b1$$udzne
000257583 7001_ $$aKunadt, Marcel$$b2
000257583 7001_ $$aKoel-Simmelink, Marleen$$b3
000257583 7001_ $$aBoiten, Walter$$b4
000257583 7001_ $$aPiepkorn, Lars$$b5
000257583 7001_ $$aPham, Thang V$$b6
000257583 7001_ $$aChiasserini, Davide$$b7
000257583 7001_ $$aPiersma, Sander R$$b8
000257583 7001_ $$aKnol, Jaco C$$b9
000257583 7001_ $$aMöbius, Wiebke$$b10
000257583 7001_ $$0P:(DE-2719)9001340$$aMollenhauer, Brit$$b11$$udzne
000257583 7001_ $$avan der Flier, Wiesje M$$b12
000257583 7001_ $$aJimenez, Connie R$$b13
000257583 7001_ $$aTeunissen, Charlotte E$$b14
000257583 7001_ $$aJahn, Olaf$$b15
000257583 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b16$$eLast author
000257583 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.13066$$gp. alz.13066$$n11$$p4828 - 4840$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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