% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Chatterjee:257583,
      author       = {Chatterjee, Madhurima and Özdemir, Selcuk and Kunadt,
                      Marcel and Koel-Simmelink, Marleen and Boiten, Walter and
                      Piepkorn, Lars and Pham, Thang V and Chiasserini, Davide and
                      Piersma, Sander R and Knol, Jaco C and Möbius, Wiebke and
                      Mollenhauer, Brit and van der Flier, Wiesje M and Jimenez,
                      Connie R and Teunissen, Charlotte E and Jahn, Olaf and
                      Schneider, Anja},
      title        = {{C}1q is increased in cerebrospinal fluid-derived
                      extracellular vesicles in {A}lzheimer's disease: {A}
                      multi-cohort proteomics and immuno-assay validation study.},
      journal      = {Alzheimer's and dementia},
      volume       = {19},
      number       = {11},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2023-00459},
      pages        = {4828 - 4840},
      year         = {2023},
      abstract     = {Extracellular vesicles (EVs) may propagate and modulate
                      Alzheimer's disease (AD) pathology. We aimed to
                      comprehensively characterize the proteome of cerebrospinal
                      fluid (CSF) EVs to identify proteins and pathways altered in
                      AD.CSF EVs were isolated by ultracentrifugation (Cohort 1)
                      or Vn96 peptide (Cohort 2) from non-neurodegenerative
                      controls (n = 15, 16) and AD patients (n = 22, 20,
                      respectively). EVs were subjected to untargeted quantitative
                      mass spectrometry-based proteomics. Results were validated
                      by enzyme-linked immunosorbent assay (ELISA) in Cohorts 3
                      and 4, consisting of controls (n = 16, n = 43, (Cohort3,
                      Cohort4)), and patients with AD (n = 24, n = 100).We found >
                      30 differentially expressed proteins in AD CSF EVs involved
                      in immune-regulation. Increase of C1q levels in AD compared
                      to non-demented controls was validated by ELISA (∼ 1.5
                      fold, p (Cohort 3) = 0.03, p (Cohort 4) = 0.005).EVs may be
                      utilized as a potential biomarker and may play a so far
                      unprecedented role in immune-regulation in AD.},
      keywords     = {Humans / Alzheimer Disease: pathology / Complement C1q /
                      Proteomics / Amyloid beta-Peptides: metabolism / Peptide
                      Fragments: cerebrospinal fluid / Biomarkers: cerebrospinal
                      fluid / Extracellular Vesicles: metabolism / tau Proteins:
                      cerebrospinal fluid / Cognitive Dysfunction: cerebrospinal
                      fluid / Complement C1q (NLM Chemicals) / Alzheimer's disease
                      (AD) (Other) / biomarker (Other) / cerebrospinal fluid (CSF)
                      (Other) / complement (Other) / extracellular vesicles
                      (Other) / immune system (Other) / mild cognitive impairment
                      (MCI) (Other) / proteomics (Other) / Amyloid beta-Peptides
                      (NLM Chemicals) / Peptide Fragments (NLM Chemicals) /
                      Biomarkers (NLM Chemicals) / tau Proteins (NLM Chemicals)},
      cin          = {AG Schneider},
      ddc          = {610},
      cid          = {I:(DE-2719)1011305},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37023079},
      doi          = {10.1002/alz.13066},
      url          = {https://pub.dzne.de/record/257583},
}