engVitale, IlioPietrocola, FedericoAmelio, IvanoKarin, MichaelKashkar, HamidKaufmann, ThomasKelly, Gemma LKepp, OliverKimchi, AdiKitsis, Richard NKlionsky, Daniel JKluck, RuthKrysko, Dmitri VAndrews, David WKulms, DagmarKumar, SharadLavandero, SergioLavrik, Inna NLemasters, John JLiccardi, GianmariaLinkermann, AndreasLipton, Stuart ALockshin, Richard ALópez-Otín, CarlosAqeilan, Rami ILuedde, TomMacFarlane, MarionMadeo, FrankMalorni, WalterManic, GwenolaMantovani, RobertoMarchi, SaverioMarine, Jean-ChristopheMartin, Seamus JMartinou, Jean-ClaudeArama, EliMastroberardino, Pier GMedema, Jan PaulMehlen, PatrickMeier, PascalMelino, GerryMelino, SoniaMiao, Edward AMoll, Ute MMuñoz-Pinedo, CristinaMurphy, Daniel JBaehrecke, Eric HNiklison-Chirou, Maria VictoriaNovelli, FlaviaNúñez, GabrielOberst, AndrewOfengeim, DimitryOpferman, Joseph TOren, MoshePagano, MichelePanaretakis, TheocharisPasparakis, ManolisBalachandran, SiddharthPenninger, Josef MPentimalli, FrancescaPereira, David MPervaiz, ShazibPeter, Marcus EPinton, PaoloPorta, GiovanniPrehn, Jochen H MPuthalakath, HamsaRabinovich, Gabriel ABano, DanieleRajalingam, KrishnarajRavichandran, Kodi SRehm, MarkusRicci, Jean-EhrlandRizzuto, RosarioRobinson, NirmalRodrigues, Cecilia M PRotblat, BarakRothlin, Carla VRubinsztein, David CBarlev, Nickolai ARudel, ThomasRufini, AlessandroRyan, Kevin MSarosiek, Kristopher ASawa, AkiraSayan, EmreSchroder, KateScorrano, LucaSesti, FedericoShao, FengBartek, JiriShi, YufangSica, Giuseppe SSilke, JohnSimon, Hans-UweSistigu, AntonellaStephanou, AnastasisStockwell, Brent RStrapazzon, FlavieStrasser, AndreasSun, LimingBazan, Nicolas GSun, ErweiSun, QiangSzabadkai, GyorgyTait, Stephen W GTang, DaolinTavernarakis, NektariosTroy, Carol MTurk, BorisUrbano, NicolettaVandenabeele, PeterGuilbaud, EmmaBecker, ChristophVanden Berghe, TomVander Heiden, Matthew GVanderluit, Jacqueline LVerkhratsky, AlexeiVillunger, Andreasvon Karstedt, SilviaVoss, Anne KVousden, Karen HVucic, DomagojVuri, DanielaBernassola, FrancescaWagner, Erwin FWalczak, HenningWallach, DavidWang, RuoningWang, YingWeber, AchimWood, WillYamazaki, TakahiroYang, Huang-TianZakeri, ZahraBertrand, Mathieu J MZawacka-Pankau, Joanna EZhang, LinZhang, HaibingZhivotovsky, BorisZhou, WenzhaoPiacentini, MauroKroemer, GuidoGalluzzi, LorenzoBianchi, Marco EBlagosklonny, Mikhail VBlander, J MagarianBlandino, GiovanniBlomgren, KlasBorner, ChristophBortner, Carl DAaronson, Stuart ABove, PierluigiBoya, PatriciaBrenner, CatherineBroz, PetrBrunner, ThomasDamgaard, Rune BuskCalin, George ACampanella, MichelangeloCandi, EleonoraCarbone, MicheleAbrams, John MCarmona-Gutierrez, DidacCecconi, FrancescoChan, Francis K-MChen, Guo-QiangChen, QuanChen, Youhai HCheng, Emily HChipuk, Jerry ECidlowski, John ACiechanover, AaronAdam, DieterCiliberto, GennaroConrad, MarcusCubillos-Ruiz, Juan RCzabotar, Peter ED'Angiolella, VincenzoDaugaard, MadsDawson, Ted MDawson, Valina LDe Maria, RuggeroDe Strooper, BartAgostini, MassimilianoDebatin, Klaus-MichaelDeberardinis, Ralph JDegterev, AlexeiDel Sal, GianninoDeshmukh, MohanishDi Virgilio, FrancescoDiederich, MarcDixon, Scott JDynlacht, Brian DEl-Deiry, Wafik SAgostinis, PatriziaElrod, John WEngeland, KurtFimia, Gian MariaGalassi, ClaudiaGanini, CarloGarcia-Saez, Ana JGarg, Abhishek DGarrido, CarmenGavathiotis, EvripidisGerlic, MottiAlnemri, Emad SGhosh, SouravGreen, Douglas RGreene, Lloyd AGronemeyer, HinrichHäcker, GeorgHajnóczky, GyörgyHardwick, J MarieHaupt, YgalHe, SudanHeery, David MAltucci, LuciaHengartner, Michael OHetz, ClaudioHildeman, David AIchijo, HidenoriInoue, SatoshiJäättelä, MarjaJanic, AnaJoseph, BertrandJost, Philipp JKanneganti, Thirumala-DeviApoptotic cell death in disease-Current understanding of the NCCD 2023.info:eu-repo/classification/ddc/610AnimalsHumansApoptosis: geneticsCell DeathCaspases: geneticsCaspases: metabolismCarcinogenesisMammals: metabolismCaspasesApoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.Cell death and differentiation 30(5), 1097 - 1154 (2023). doi:10.1038/s41418-023-01153-winfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionMacmillan2023info:eu-repo/semantics/closedAccessDEhttps://pub.dzne.de/record/257894https://pub.dzne.de/search?p=id:%22DZNE-2023-00522%22Researchersinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41418-023-01153-winfo:eu-repo/semantics/altIdentifier/issn/1350-9047info:eu-repo/semantics/altIdentifier/issn/1476-5403info:eu-repo/semantics/altIdentifier/pmid/pmid:37100955