257894 20240624140128.0 10.1038/s41418-023-01153-w doi pmid:37100955 pmid pmc:PMC10130819 pmc 1350-9047 ISSN 1476-5403 ISSN altmetric:146597612 altmetric DZNE-2023-00522 English 610 Vitale, Ilio 0000-0002-5918-1841 0 Apoptotic cell death in disease-Current understanding of the NCCD 2023. London 2023 Macmillan article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1719230442_2987 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Caspases EC 3.4.22.- NLM Chemicals Animals MeSH Humans MeSH Apoptosis: genetics MeSH Cell Death MeSH Caspases: genetics MeSH Caspases: metabolism MeSH Carcinogenesis MeSH Mammals: metabolism MeSH Pietrocola, Federico 1 Guilbaud, Emma 2 Aaronson, Stuart A 3 Abrams, John M 4 Adam, Dieter 5 Agostini, Massimiliano 6 Agostinis, Patrizia 7 Alnemri, Emad S 8 Altucci, Lucia 9 Amelio, Ivano 10 Andrews, David W 11 Aqeilan, Rami I 12 Arama, Eli 13 Baehrecke, Eric H 14 Balachandran, Siddharth 15 Bano, Daniele P:(DE-2719)2158358 16 dzne Barlev, Nickolai A 17 Bartek, Jiri 18 Bazan, Nicolas G 19 Becker, Christoph 20 Bernassola, Francesca 21 Bertrand, Mathieu J M 22 Bianchi, Marco E 23 Blagosklonny, Mikhail V 24 Blander, J Magarian 25 Blandino, Giovanni 26 Blomgren, Klas 27 Borner, Christoph 28 Bortner, Carl D 29 Bove, Pierluigi 30 Boya, Patricia 31 Brenner, Catherine 32 Broz, Petr 33 Brunner, Thomas 34 Damgaard, Rune Busk 35 Calin, George A 36 Campanella, Michelangelo 37 Candi, Eleonora 38 Carbone, Michele 39 Carmona-Gutierrez, Didac 40 Cecconi, Francesco 41 Chan, Francis K-M 42 Chen, Guo-Qiang 43 Chen, Quan 44 Chen, Youhai H 45 Cheng, Emily H 46 Chipuk, Jerry E 47 Cidlowski, John A 48 Ciechanover, Aaron 49 Ciliberto, Gennaro 50 Conrad, Marcus P:(DE-HGF)0 51 Cubillos-Ruiz, Juan R 52 Czabotar, Peter E 53 D'Angiolella, Vincenzo 54 Daugaard, Mads 55 Dawson, Ted M 56 Dawson, Valina L 57 De Maria, Ruggero 58 De Strooper, Bart 59 Debatin, Klaus-Michael 60 Deberardinis, Ralph J 61 Degterev, Alexei 62 Del Sal, Giannino 63 Deshmukh, Mohanish 64 Di Virgilio, Francesco 65 Diederich, Marc 66 Dixon, Scott J 67 Dynlacht, Brian D 68 El-Deiry, Wafik S 69 Elrod, John W 70 Engeland, Kurt 71 Fimia, Gian Maria 72 Galassi, Claudia 73 Ganini, Carlo 74 Garcia-Saez, Ana J 75 Garg, Abhishek D 76 Garrido, Carmen 77 Gavathiotis, Evripidis 78 Gerlic, Motti 79 Ghosh, Sourav 80 Green, Douglas R 81 Greene, Lloyd A 82 Gronemeyer, Hinrich 83 Häcker, Georg 84 Hajnóczky, György 85 Hardwick, J Marie 86 Haupt, Ygal 87 He, Sudan 88 Heery, David M 89 Hengartner, Michael O 90 Hetz, Claudio 91 Hildeman, David A 92 Ichijo, Hidenori 93 Inoue, Satoshi 94 Jäättelä, Marja 95 Janic, Ana 96 Joseph, Bertrand 97 Jost, Philipp J 98 Kanneganti, Thirumala-Devi 99 Karin, Michael 100 Kashkar, Hamid 101 Kaufmann, Thomas 102 Kelly, Gemma L 103 Kepp, Oliver 104 Kimchi, Adi 105 Kitsis, Richard N 106 Klionsky, Daniel J 107 Kluck, Ruth 108 Krysko, Dmitri V 109 Kulms, Dagmar 110 Kumar, Sharad 111 Lavandero, Sergio 112 Lavrik, Inna N 113 Lemasters, John J 114 Liccardi, Gianmaria 115 Linkermann, Andreas 116 Lipton, Stuart A 117 Lockshin, Richard A 118 López-Otín, Carlos 119 Luedde, Tom 120 MacFarlane, Marion 121 Madeo, Frank 122 Malorni, Walter 123 Manic, Gwenola 124 Mantovani, Roberto 125 Marchi, Saverio 126 Marine, Jean-Christophe 127 Martin, Seamus J 128 Martinou, Jean-Claude 129 Mastroberardino, Pier G 130 Medema, Jan Paul 131 Mehlen, Patrick 132 Meier, Pascal 133 Melino, Gerry P:(DE-2719)9001390 134 dzne Melino, Sonia 135 Miao, Edward A 136 Moll, Ute M 137 Muñoz-Pinedo, Cristina 138 Murphy, Daniel J 139 Niklison-Chirou, Maria Victoria 140 Novelli, Flavia 141 Núñez, Gabriel 142 Oberst, Andrew 143 Ofengeim, Dimitry 144 Opferman, Joseph T 145 Oren, Moshe 146 Pagano, Michele 147 Panaretakis, Theocharis 148 Pasparakis, Manolis 149 Penninger, Josef M 150 Pentimalli, Francesca 151 Pereira, David M 152 Pervaiz, Shazib 153 Peter, Marcus E 154 Pinton, Paolo 155 Porta, Giovanni 156 Prehn, Jochen H M 157 Puthalakath, Hamsa 158 Rabinovich, Gabriel A 159 Rajalingam, Krishnaraj 160 Ravichandran, Kodi S 161 Rehm, Markus 162 Ricci, Jean-Ehrland 163 Rizzuto, Rosario 164 Robinson, Nirmal 165 Rodrigues, Cecilia M P 166 Rotblat, Barak 167 Rothlin, Carla V 168 Rubinsztein, David C 169 Rudel, Thomas 170 Rufini, Alessandro 171 Ryan, Kevin M 172 Sarosiek, Kristopher A 173 Sawa, Akira 174 Sayan, Emre 175 Schroder, Kate 176 Scorrano, Luca 177 Sesti, Federico 178 Shao, Feng 179 Shi, Yufang 180 Sica, Giuseppe S 181 Silke, John 182 Simon, Hans-Uwe 183 Sistigu, Antonella 184 Stephanou, Anastasis 185 Stockwell, Brent R 186 Strapazzon, Flavie 187 Strasser, Andreas 188 Sun, Liming 189 Sun, Erwei 190 Sun, Qiang 191 Szabadkai, Gyorgy 192 Tait, Stephen W G 193 Tang, Daolin 194 Tavernarakis, Nektarios 195 Troy, Carol M 196 Turk, Boris 197 Urbano, Nicoletta 198 Vandenabeele, Peter 199 Vanden Berghe, Tom 200 Vander Heiden, Matthew G 201 Vanderluit, Jacqueline L 202 Verkhratsky, Alexei 203 Villunger, Andreas 204 von Karstedt, Silvia 205 Voss, Anne K 206 Vousden, Karen H 207 Vucic, Domagoj 208 Vuri, Daniela 209 Wagner, Erwin F 210 Walczak, Henning 211 Wallach, David 212 Wang, Ruoning 213 Wang, Ying 214 Weber, Achim 215 Wood, Will 216 Yamazaki, Takahiro 217 Yang, Huang-Tian 218 Zakeri, Zahra 219 Zawacka-Pankau, Joanna E 220 Zhang, Lin 221 Zhang, Haibing 222 Zhivotovsky, Boris 223 Zhou, Wenzhao 224 Piacentini, Mauro 0000-0003-2919-1296 225 Kroemer, Guido 0000-0002-9334-4405 226 Galluzzi, Lorenzo 0000-0003-2257-8500 227 10.1038/s41418-023-01153-w Vol. 30, no. 5, p. 1097 - 1154 PERI:(DE-600)1496681-5 5 1097 - 1154 Cell death and differentiation 30 2023 1350-9047 http://pub.dzne.de/record/257894/files/DZNE-2023-00522_Restricted.pdf http://pub.dzne.de/record/257894/files/DZNE-2023-00522_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:257894 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 16 P:(DE-2719)2158358 External Institute I:(DE-HGF)0 Extern 134 P:(DE-2719)9001390 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF 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