257999 20231126001815.0 10.1523/JNEUROSCI.1692-22.2023 doi pmid:37001994 pmid pmc:PMC10184749 pmc 0270-6474 ISSN 1529-2401 ISSN altmetric:155248259 altmetric DZNE-2023-00529 English 610 Döhler, Juliane P:(DE-2719)2812088 0 First author dzne The 3D Structural Architecture of the Human Hand Area Is Nontopographic. Washington, DC 2023 Soc. article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1686662400_29081 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The functional topography of the human primary somatosensory cortex hand area is a widely studied model system to understand sensory organization and plasticity. It is so far unclear whether the underlying 3D structural architecture also shows a topographic organization. We used 7 Tesla (7T) magnetic resonance imaging (MRI) data to quantify layer-specific myelin, iron, and mineralization in relation to population receptive field maps of individual finger representations in Brodman area 3b (BA 3b) of human S1 in female and male younger adults. This 3D description allowed us to identify a characteristic profile of layer-specific myelin and iron deposition in the BA 3b hand area, but revealed an absence of structural differences, an absence of low-myelin borders, and high similarity of 3D microstructure profiles between individual fingers. However, structural differences and borders were detected between the hand and face areas. We conclude that the 3D structural architecture of the human hand area is nontopographic, unlike in some monkey species, which suggests a high degree of flexibility for functional finger organization and a new perspective on human topographic plasticity.SIGNIFICANCE STATEMENT Using ultra-high-field MRI, we provide the first comprehensive in vivo description of the 3D structural architecture of the human BA 3b hand area in relation to functional population receptive field maps. High similarity of precise finger-specific 3D profiles, together with an absence of structural differences and an absence of low-myelin borders between individual fingers, reveals the 3D structural architecture of the human hand area to be nontopographic. This suggests reduced structural limitations to cortical plasticity and reorganization and allows for shared representational features across fingers. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de UHF MRI Other cortical field Other in vivo myeloarchitecture Other parcellation Other quantitative imaging Other septa Other Adult MeSH Humans MeSH Male MeSH Female MeSH Somatosensory Cortex MeSH Hand MeSH Fingers MeSH Cerebral Cortex MeSH Magnetic Resonance Imaging MeSH Brain Mapping: methods MeSH Northall, Alicia P:(DE-2719)9000681 1 dzne Liu, Peng P:(DE-2719)9000645 2 dzne Fracasso, Alessio 3 Chrysidou, Anastasia P:(DE-2719)9001858 4 dzne Speck, Oliver P:(DE-2719)2810706 5 dzne Lohmann, Gabriele 6 Wolbers, Thomas P:(DE-2719)2810583 7 dzne Kuehn, Esther P:(DE-2719)9001179 8 Last author dzne 10.1523/JNEUROSCI.1692-22.2023 Vol. 43, no. 19, p. 3456 - 3476 PERI:(DE-600)1475274-8 19 3456 - 3476 The journal of neuroscience 43 2023 0270-6474 https://www.jneurosci.org/content/43/19/3456 http://pub.dzne.de/record/257999/files/DZNE-2023-00529.pdf OpenAccess http://pub.dzne.de/record/257999/files/DZNE-2023-00529.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:257999 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2812088 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9000681 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9000645 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9001858 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2810706 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2810583 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)9001179 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2023 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2022-11-13 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2022-11-13 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2022-11-13 OpenAccess StatID:(DE-HGF)0510 StatID Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-10-21 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-10-21 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2023-10-21 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-10-21 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-10-21 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-10-21 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2023-10-21 JCR StatID:(DE-HGF)0100 StatID J NEUROSCI : 2022 2023-10-21 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-10-21 Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-10-21 IF >= 5 StatID:(DE-HGF)9905 StatID J NEUROSCI : 2022 2023-10-21 I:(DE-2719)1210000 AG Gasser Parkinson Genetics 0 I:(DE-2719)5000006 AG Düzel 3 Clinical Neurophysiology and Memory 1 I:(DE-2719)1310010 AG Schreiber Mixed Cerebral Pathologies and Cognitive Aging 2 I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 3 I:(DE-2719)1340009 AG Speck Linking imaging projects iNET 4 journal VDB UNRESTRICTED I:(DE-2719)1210000-7 I:(DE-2719)5000006 I:(DE-2719)1310010 I:(DE-2719)1310002 I:(DE-2719)1340009 FullTexts