258784 20240112171543.0 10.3233/JAD-221153 doi pmid:37182873 pmid 1387-2877 ISSN 1875-8908 ISSN altmetric:148270624 altmetric DZNE-2023-00678 English 610 Rakuša, Elena P:(DE-2719)9001401 0 First author dzne Sporadic Use of Antibiotics in Older Adults and the Risk of Dementia: A Nested Case-Control Study Based on German Health Claims Data. Amsterdam 2023 IOS Press article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1689240314_15886 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Antibiotics for systemic use may increase the risk of neurodegeneration, yet antibiotic therapy may be able to halt or mitigate an episode of neurodegenerative decline.To investigate the association of sporadic use of antibiotics and subsequent dementia risk (including Alzheimer's disease).We used data from the largest public health insurance fund in Germany, the Allgemeine Ortskrankenkasse (AOK). Each of the 35,072 dementia cases aged 60 years and older with a new dementia diagnosis during the observation period from 2006 to 2018 was matched with two control-patients by age, sex, and time since 2006. We ran conditional logistic regression models for dementia risk in terms of odds ratios (OR) as a function of antibiotic use for the entire antibiotic group and for each antibiotic subgroup. We controlled for comorbidities, need for long-term care, hospitalizations, and nursing home placement.Antibiotic use was positively associated with dementia (OR = 1.18, 95% confidence interval (95% CI):1.14-1.22), which became negative after adjustment for comorbidities, at least one diagnosis of bacterial infection or disease, and covariates (OR = 0.93, 95% CI:0.90-0.96). Subgroups of antibiotics were also negatively associated with dementia after controlling for covariates: tetracyclines (OR = 0.94, 95% CI:0.90-0.98), beta-lactam antibacterials, penicillins (OR = 0.93, 95% CI:0.90-0.97), other beta-lactam antibacterials (OR = 0.92, 95% CI:0.88-0.95), macrolides, lincosamides, and streptogramins (OR = 0.88, 95% CI:0.85-0.92), and quinolone antibacterials (OR = 0.96, 95% CI:0.92-0.99).Our results suggest that there was a decreased likelihood of dementia for preceding antibiotic use. The benefits of antibiotics in reducing inflammation and thus the risk of dementia need to be carefully weighed against the increase in antibiotic resistance. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Humans MeSH Middle Aged MeSH Aged MeSH Anti-Bacterial Agents: adverse effects MeSH Case-Control Studies MeSH Comorbidity MeSH Dementia: drug therapy MeSH Dementia: epidemiology MeSH Dementia: diagnosis MeSH beta-Lactams MeSH Alzheimer’s disease Other Alzheimer’s disease Other antibiotics Other conditional logistic regression Other dementia Other epidemiology Other nested case-control studies Other Anti-Bacterial Agents NLM Chemicals beta-Lactams NLM Chemicals Fink, Anne P:(DE-2719)2241493 1 dzne Tamgüney, Gültekin P:(DE-2719)2810376 2 dzne Heneka, Michael P:(DE-2719)2000008 3 dzne Doblhammer, Gabriele P:(DE-2719)2811246 4 Last author dzne 10.3233/JAD-221153 Vol. 93, no. 4, p. 1329 - 1339 PERI:(DE-600)2070772-1 4 1329 - 1339 Journal of Alzheimer's disease 93 2023 1387-2877 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad221153 http://pub.dzne.de/record/258784/files/DZNE-2023-00678_Restricted.pdf http://pub.dzne.de/record/258784/files/DZNE-2023-00678_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:258784 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9001401 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2241493 External Institute I:(DE-HGF)0 Extern 2 P:(DE-2719)2810376 External Institute I:(DE-HGF)0 Extern 3 P:(DE-2719)2000008 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2811246 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 2023 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2022-11-18 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2022-11-18 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2022-11-18 JCR StatID:(DE-HGF)0100 StatID J ALZHEIMERS DIS : 2022 2023-08-25 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-25 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-25 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-08-25 Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-08-25 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-25 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-08-25 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-25 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2023-08-25 IF < 5 StatID:(DE-HGF)9900 StatID 2023-08-25 I:(DE-2719)1012002 AG Doblhammer-Reiter Demographic Studies 0 journal VDB I:(DE-2719)1012002 UNRESTRICTED