267496 20240403131602.0 10.1007/s11060-023-04547-5 doi pmid:38253790 pmid pmc:PMC10834633 pmc 0167-594X ISSN 1573-7373 ISSN altmetric:158649899 altmetric DZNE-2024-00142 English 610 Obrecht-Sturm, Denise 0000-0002-3216-8452 0 Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment. Dordrecht [u.a.] 2024 Springer Science + Business Media B.V article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1707823918_13996 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote To provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).Prospectively collected data of three patients with pineal anlage tumor from Germany was combined with clinical details and treatment information from 17 published cases.Overall, 20 cases of PAT were identified (3 not previously reported German cases, 17 cases from published reports). Age at diagnosis ranged from 0.3 to 35.0 (median: 3.2 ± 7.8) years. All but three cases were diagnosed before the age of three years. For three cases, metastatic disease at initial staging was described. All patients underwent tumor surgery (gross-total resection: 9, subtotal resection/biopsy: 9, extent of resection unknown: 2). 15/20 patients were alive at last follow-up. Median follow-up for 10/15 surviving patients with available follow-up and treatment data was 2.4 years (0.3-6.5). Relapse was reported for 3 patients within 0.8 years after diagnosis. Five patients died, 3 after relapse and 2 from early postoperative complications. Two-year-progression-free- and -overall survival were 65.2 ± 12.7% and 49.2 ± 18.2%, respectively. All 4 patients who received intensive chemotherapy including high-dose chemotherapy combined with radiotherapy (2 focal, 2 craniospinal [CSI]) had no recurrence. Focal radiotherapy- and CSI-free survival rates in 13 evaluable patients were 46.2% (6/13) and 61.5% (8/13), respectively.PAT is an aggressive disease mostly affecting young children. Therefore, adjuvant therapy using intensive chemotherapy and considering radiotherapy appears to comprise an appropriate treatment strategy. Reporting further cases is crucial to evaluate distinct treatment strategies. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de PINEAL anlage tumor Other Pineal gland Other Pineoblastoma Other Child MeSH Humans MeSH Child, Preschool MeSH Infant MeSH Adolescent MeSH Young Adult MeSH Adult MeSH Treatment Outcome MeSH Pineal Gland: surgery MeSH Pineal Gland: pathology MeSH Neoplasm Recurrence, Local: pathology MeSH Pinealoma: diagnosis MeSH Pinealoma: surgery MeSH Supratentorial Neoplasms: pathology MeSH Brain Neoplasms: diagnosis MeSH Brain Neoplasms: surgery MeSH Recurrence MeSH Pfaff, Elke 1 Mynarek, Martin 2 Bison, Brigitte 3 Rodehüser, Martina 4 Becker, Martina 5 Kietz, Silke 6 Pfister, Stefan M 7 Jones, David T 8 Sturm, Dominik 9 von Deimling, Andreas 10 Sahm, Felix 11 Kortmann, Rolf-Dieter 12 Schwarz, Rudolf 13 Pietsch, Torsten P:(DE-2719)2812617 14 dzne Fleischhack, Gudrun 15 Rutkowski, Stefan 16 10.1007/s11060-023-04547-5 Vol. 166, no. 2, p. 359 - 368 PERI:(DE-600)2007293-4 2 359 - 368 Journal of neuro-oncology 166 2024 0167-594X http://pub.dzne.de/record/267496/files/DZNE-2024-00142%20SUP.pdf OpenAccess http://pub.dzne.de/record/267496/files/DZNE-2024-00142.pdf pdfa http://pub.dzne.de/record/267496/files/DZNE-2024-00142%20SUP.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/267496/files/DZNE-2024-00142.pdf?subformat=pdfa oai:pub.dzne.de:267496 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 14 P:(DE-2719)2812617 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2024 OpenAccess StatID:(DE-HGF)0510 StatID Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC Nationallizenz StatID:(DE-HGF)0420 StatID 2023-08-20 ger JCR StatID:(DE-HGF)0100 StatID J NEURO-ONCOL : 2022 2023-08-20 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-20 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-20 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-20 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-20 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2023-08-20 IF < 5 StatID:(DE-HGF)9900 StatID 2023-08-20 I:(DE-2719)1011009 Brainbank Unit Bonn Brainbank Unit Bonn 0 journal VDB UNRESTRICTED I:(DE-2719)1011009 FullTexts