268859 20260107151727.0 10.4161/bioa.26259 doi pmid:24002528 pmid pmc:PMC4201609 pmc 1949-0992 ISSN 1949-100X ISSN altmetric:1775994 altmetric DZNE-2024-00358 English 570 Flynn, Kevin P:(DE-2719)2810272 0 First author The cytoskeleton and neurite initiation. Austin, Tex. 2013 Landes Bioscience article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1713178841_9657 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Neurons begin their life as simple spheres, but can ultimately assume an elaborate morphology with numerous, highly arborized dendrites, and long axons. This is achieved via an astounding developmental progression which is dependent upon regulated assembly and dynamics of the cellular cytoskeleton. As neurites emerge out of the soma, neurons break their spherical symmetry and begin to acquire the morphological features that define their structure and function. Neurons regulate their cytoskeleton to achieve changes in cell shape, velocity, and direction as they migrate, extend neurites, and polarize. Of particular importance, the organization and dynamics of actin and microtubules directs the migration and morphogenesis of neurons. This review focuses on the regulation of intrinsic properties of the actin and microtubule cytoskeletons and how specific cytoskeletal structures and dynamics are associated with the earliest phase of neuronal morphogenesis—neuritogenesis. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Actins NLM Chemicals Actins: metabolism MeSH Animals MeSH Cytoskeleton: metabolism MeSH Humans MeSH Morphogenesis MeSH Neurites: metabolism MeSH Neurons: cytology MeSH Neurons: metabolism MeSH 10.4161/bioa.26259 Vol. 3, no. 4, p. 86 - 109 PERI:(DE-600)2628854-0 4 86 - 109 BioArchitecture 3 2013 1949-0992 http://pub.dzne.de/record/268859/files/DZNE-2024-00358_Restricted.pdf http://pub.dzne.de/record/268859/files/DZNE-2024-00358_Restricted.pdf?subformat=pdfa pdfa oai:pub.dzne.de:268859 VDB Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810272 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 2013 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-26 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-26 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2023-08-26 I:(DE-2719)1013002 AG Bradke Axon Growth and Regeneration 0 journal VDB I:(DE-2719)1013002 UNRESTRICTED