269188 20240808164534.0 10.1038/s44318-024-00067-8 doi pmid:38528182 pmid pmc:PMC11021462 pmc 0261-4189 ISSN 1460-2075 ISSN altmetric:161180588 altmetric DZNE-2024-00487 English 570 Kaurani, Lalit P:(DE-2719)2812832 0 First author Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. Hoboken, NJ [u.a.] 2024 Wiley article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1713865687_10932 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have received less attention. In the present study, we analyze the microRNAome in the blood and postmortem brains of schizophrenia patients, showing that the expression of miR-99b-5p is downregulated in both the prefrontal cortex and blood of patients. Lowering the amount of miR-99b-5p in mice leads to both schizophrenia-like phenotypes and inflammatory processes that are linked to synaptic pruning in microglia. The microglial miR-99b-5p-supressed inflammatory response requires Z-DNA binding protein 1 (Zbp1), which we identify as a novel miR-99b-5p target. Antisense oligonucleotides against Zbp1 ameliorate the pathological effects of miR-99b-5p inhibition. Our findings indicate that a novel miR-99b-5p-Zbp1 pathway in microglia might contribute to the pathogenesis of schizophrenia. 352 - Disease Mechanisms (POF4-352) G:(DE-HGF)POF4-352 POF4-352 POF IV 0 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de RNA-Binding Proteins: metabolism MeSH Humans MeSH Animals MeSH Mice MeSH Microglia: metabolism MeSH Schizophrenia: genetics MeSH MicroRNAs: metabolism MeSH RNA-Binding Proteins MeSH Mirn99 microRNA, mouse NLM Chemicals Microglia Other Schizophrenia Other Zbp1 Other miR-99b Other microRNA Other MicroRNAs NLM Chemicals Zbp1 protein, mouse NLM Chemicals RNA-Binding Proteins NLM Chemicals Islam, Rezaul P:(DE-2719)2811643 1 First author dzne Heilbronner, Urs 2 Krüger, Dennis M P:(DE-2719)2812548 3 dzne Zhou, Jiayin P:(DE-2719)9001020 4 dzne Methi, Aditi P:(DE-2719)9001018 5 dzne Strauss, Judith 6 Pradhan, Ranjit P:(DE-2719)9001438 7 dzne Schröder, Sophie P:(DE-2719)9001406 8 dzne Burkhardt, Susanne P:(DE-2719)2810773 9 dzne Schuetz, Anna-Lena P:(DE-2719)2810585 10 dzne Pena, Tonatiuh P:(DE-2719)2811063 11 Erlebach, Lena P:(DE-2719)9000542 12 dzne Bühler, Anika P:(DE-2719)2813030 13 dzne Budde, Monika 14 Senner, Fanny 15 Kohshour, Mojtaba Oraki 16 Schulte, Eva C 17 Schmauß, Max 18 Reininghaus, Eva Z 19 Juckel, Georg 20 Kronenberg-Versteeg, Deborah P:(DE-2719)9001451 21 dzne Delalle, Ivana 22 Odoardi, Francesca 23 Flügel, Alexander 24 Schulze, Thomas G 0000-0001-6624-2975 25 Falkai, Peter P:(DE-2719)2811040 26 Sananbenesi, Farahnaz P:(DE-2719)2811099 27 dzne Fischer, Andre P:(DE-2719)2000047 28 10.1038/s44318-024-00067-8 Vol. 43, no. 8, p. 1420 - 1444 PERI:(DE-600)1467419-1 8 1420 - 1444 The EMBO journal 43 2024 0261-4189 http://pub.dzne.de/record/269188/files/DZNE-2024-00487%20SUP.zip OpenAccess http://pub.dzne.de/record/269188/files/DZNE-2024-00487.pdf OpenAccess pdfa http://pub.dzne.de/record/269188/files/DZNE-2024-00487.pdf?subformat=pdfa oai:pub.dzne.de:269188 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2812832 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2811643 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2812548 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9001020 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)9001018 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)9001438 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)9001406 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2810773 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 10 P:(DE-2719)2810585 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 11 P:(DE-2719)2811063 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 12 P:(DE-2719)9000542 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 13 P:(DE-2719)2813030 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 21 P:(DE-2719)9001451 External Institute I:(DE-HGF)0 Extern 27 P:(DE-2719)2811099 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 28 P:(DE-2719)2000047 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-352 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Mechanisms 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 1 2024 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-24 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2023-08-24 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-08-24 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2023-08-24 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-08-24 JCR StatID:(DE-HGF)0100 StatID EMBO J : 2022 2023-08-24 IF >= 10 StatID:(DE-HGF)9910 StatID EMBO J : 2022 2023-08-24 DEAL Wiley StatID:(DE-HGF)3001 StatID 2023-08-24 ger WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2023-08-24 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2023-08-24 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-24 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-08-24 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-24 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2023-08-24 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-24 I:(DE-2719)1410002 AG Fischer Epigenetics and Systems Medicine in Neurodegenerative Diseases 0 I:(DE-2719)1210015 AG Kronenberg-Versteeg Glial Cell Biology 1 I:(DE-2719)1210001 AG Jucker Cell Biology of Neurological Diseases 2 journal VDB UNRESTRICTED I:(DE-2719)1410002 I:(DE-2719)1210015 I:(DE-2719)1210001 FullTexts