269678 20240809090116.0 10.1186/s13062-024-00479-w doi pmid:38755705 pmid pmc:PMC11097554 pmc altmetric:163441186 altmetric DZNE-2024-00592 English 570 Gao, Xiaoyan 0 Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression. London 2024 BioMed Central article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1716453471_3152 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. These isolated cells remarkably enhanced tumor growth when incorporated into systems alongside tumor cells in vivo. Importantly, in the presence of mesenchymal stem cells, the ability of peripheral blood mononuclear cell-derived natural killer and activated T cells to mediate tumor cell destruction was significantly compromised.Collectively, these data support the notion that human lung cancer-derived mesenchymal stem cells protect tumor cells from immune-mediated destruction by inhibiting the antitumor activities of natural killer and T cells. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Immunophenotype Other Mesenchymal stem cell Other Multipotent differentiation Other Natural killer cell Other Non-small cell lung cancer Other T cell Other Tumorigenic Other Humans MeSH Mesenchymal Stem Cells MeSH Lung Neoplasms: immunology MeSH Carcinoma, Non-Small-Cell Lung: immunology MeSH Killer Cells, Natural: immunology MeSH Animals MeSH Mice MeSH T-Lymphocytes: immunology MeSH Cell Differentiation MeSH Tumor Microenvironment MeSH Cell Line, Tumor MeSH Ren, He 1 Zhang, Zhengrong 2 Cao, Shuai 3 Zhang, Bo 4 Sun, Qiang 5 Melino, Gerry P:(DE-2719)9001390 6 dzne Huang, Hongyan 7 10.1186/s13062-024-00479-w Vol. 19, no. 1, p. 39 PERI:(DE-600)2221028-3 1 39 Biology direct 19 2024 1745-6150 OpenAccess http://pub.dzne.de/record/269678/files/DZNE-2024-00592.pdf OpenAccess pdfa http://pub.dzne.de/record/269678/files/DZNE-2024-00592.pdf?subformat=pdfa oai:pub.dzne.de:269678 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)9001390 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 2024 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-23 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2023-08-23 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-08-23 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2023-08-23 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-08-23 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2023-08-23 JCR StatID:(DE-HGF)0100 StatID BIOL DIRECT : 2022 2023-08-23 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2023-04-12T15:09:09Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2023-04-12T15:09:09Z WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2023-08-23 Fees StatID:(DE-HGF)0700 StatID 2023-08-23 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-23 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-08-23 Article Processing Charges StatID:(DE-HGF)0561 StatID 2023-08-23 IF >= 5 StatID:(DE-HGF)9905 StatID BIOL DIRECT : 2022 2023-08-23 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-23 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2023-08-23 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-23 Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Open peer review 2023-04-12T15:09:09Z I:(DE-2719)5000018 AG Nicotera Synaptic Connectivity and Neurodegeneration 0 journal VDB UNRESTRICTED I:(DE-2719)5000018 FullTexts