269784 20240808164353.0 pmc:PMC11130115 pmc 10.1007/s00018-024-05277-1 doi pmid:38801464 pmid 1420-682X ISSN 0014-4754 ISSN 1420-9071 ISSN altmetric:163994205 altmetric DZNE-2024-00619 English 610 van Veluw, Susanne J 0000-0002-7957-8643 0 Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cham (ZG) 2024 Springer International Publishing AG article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1716898045_18043 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The brain's network of perivascular channels for clearance of excess fluids and waste plays a critical role in the pathogenesis of several neurodegenerative diseases including cerebral amyloid angiopathy (CAA). CAA is the main cause of hemorrhagic stroke in the elderly, the most common vascular comorbidity in Alzheimer's disease and also implicated in adverse events related to anti-amyloid immunotherapy. Remarkably, the mechanisms governing perivascular clearance of soluble amyloid β-a key culprit in CAA-from the brain to draining lymphatics and systemic circulation remains poorly understood. This knowledge gap is critically important to bridge for understanding the pathophysiology of CAA and accelerate development of targeted therapeutics. The authors of this review recently converged their diverse expertise in the field of perivascular physiology to specifically address this problem within the framework of a Leducq Foundation Transatlantic Network of Excellence on Brain Clearance. This review discusses the overarching goal of the consortium and explores the evidence supporting or refuting the role of impaired perivascular clearance in the pathophysiology of CAA with a focus on translating observations from rodents to humans. We also discuss the anatomical features of perivascular channels as well as the biophysical characteristics of fluid and solute transport. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Brain clearance Other Cerebral amyloid angiopathy Other Cerebrospinal fluid Other Glymphatics Other IPAD Other Perivascular spaces Other Amyloid beta-Peptides NLM Chemicals Humans MeSH Brain: metabolism MeSH Brain: pathology MeSH Cerebral Amyloid Angiopathy: metabolism MeSH Cerebral Amyloid Angiopathy: pathology MeSH Animals MeSH Amyloid beta-Peptides: metabolism MeSH Glymphatic System: metabolism MeSH Glymphatic System: pathology MeSH Alzheimer Disease: metabolism MeSH Alzheimer Disease: pathology MeSH Benveniste, Helene 1 Bakker, Erik N T P 2 Carare, Roxana O 3 Greenberg, Steven M 4 Iliff, Jeffrey J 5 Lorthois, Sylvie 6 Van Nostrand, William E 7 Petzold, Gabor C P:(DE-2719)2810273 8 dzne Shih, Andy Y 9 van Osch, Matthias J P 10 10.1007/s00018-024-05277-1 Vol. 81, no. 1, p. 239 PERI:(DE-600)1458497-9 1 239 Cellular and molecular life sciences 81 2024 1420-682X OpenAccess http://pub.dzne.de/record/269784/files/DZNE-2024-00619.pdf OpenAccess pdfa http://pub.dzne.de/record/269784/files/DZNE-2024-00619.pdf?subformat=pdfa oai:pub.dzne.de:269784 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)2810273 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2024 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-10-21 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2023-10-21 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-10-21 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-10-21 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2023-10-21 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2023-10-21 DEAL Springer StatID:(DE-HGF)3002 StatID 2023-10-21 ger DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-10-21 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-10-21 DBCoverage StatID:(DE-HGF)1120 StatID BIOSIS Reviews Reports And Meetings 2023-10-21 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-10-21 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-10-21 I:(DE-2719)1013020 AG Petzold ; AG Petzold Vascular Neurology 0 journal VDB UNRESTRICTED I:(DE-2719)1013020 FullTexts