270145 20260310111149.0 10.1007/s12403-023-00622-4 doi 2451-9766 ISSN 1876-1658 ISSN 1876-1666 ISSN 2451-9685 ISSN altmetric:160671806 altmetric DZNE-2024-00743 550 Faquih, Tariq O. P:(DE-HGF)0 0 Per- and Polyfluoroalkyl Substances Concentrations are Associated with an Unfavorable Cardio-Metabolic Risk Profile: Findings from Two Population-Based Cohort Studies [Dordrecht] 2024 Springer Netherlands article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1747922696_19988 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Per- and polyfluoroalkyl substances (PFAS) are widely used and persistent chemicals, leading to ubiquitous exposure. Although high PFAS levels have been associated with an adverse cardiovascular risk profile, the distribution of levels and relations with cardio-metabolic risk markers in the general population have not been fully characterized. We assessed the association between blood levels of perfluorooctaneic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) and a range of lipoproteins and metabolites as well as clinical lipid measurements. We used data from participants of the Netherlands Epidemiology of Obesity study (NEO) (n = 584) and the Rhineland Study (n = 1962), jointly spanning an age range of 30 to 89 years. PFAS were measured with the Metabolon HD4 platform, and lipoprotein and metabolite profiles were measured using Nightingale’s nuclear magnetic resonance-spectroscopy platform, and mainly comprised lipoprotein markers. Using linear regression analyses, we quantified age-, sex-, and education-adjusted associations of PFOA, PFOS, and PFHxS with clinical lipid measurements and 224 lipoproteins and metabolites. Higher levels of PFAS, particularly PFOS and PFHxS, were associated with higher concentrations of total lipid, cholesterol and phospholipid content in most HDL, IDL, LDL, and VLDL subclasses. The effect sizes were age-dependent for the majority of the associations, with the deleterious effects of PFAS being generally stronger in people below compared to those above median age. Our observation that in the general population even low PFAS concentrations are associated with an unfavorable lipid profile, calls for further critical regulation of PFAS substances. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de EXP:(DE-2719)Rhineland Study-20190321 EXP:(DE-2719)Rhineland Study-20190321 Rhineland Study / Bonn 0 Landstra, Elvire N. P:(DE-2719)9000634 1 van Hylckama Vlieg, Astrid P:(DE-HGF)0 2 Aziz, N. Ahmad P:(DE-2719)2812578 3 Li-Gao, Ruifang P:(DE-HGF)0 4 de Mutsert, Renée P:(DE-HGF)0 5 Rosendaal, Frits R. P:(DE-HGF)0 6 Noordam, Raymond P:(DE-HGF)0 7 van Heemst, Diana P:(DE-HGF)0 8 Mook-Kanamori, Dennis O. P:(DE-HGF)0 9 van Dijk, Ko Willems P:(DE-HGF)0 10 Breteler, Monique M. B. P:(DE-2719)2810403 11 Last author 10.1007/s12403-023-00622-4 PERI:(DE-600)2847071-0 1251 - 1262 Exposure and health 16 2024 2451-9766 http://pub.dzne.de/record/270145/files/DZNE-2024-00743.pdf OpenAccess http://pub.dzne.de/record/270145/files/DZNE-2024-00743.pdf?subformat=pdfa pdfa OpenAccess #574 2600 Hybrid-OA 2026-03-09 DEAL 2025-09-09 oai:pub.dzne.de:270145 openaire open_access OpenAPC_DEAL driver VDB openCost dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9000634 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2812578 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 11 P:(DE-2719)2810403 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 2024 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-10-27 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2023-10-27 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC JCR StatID:(DE-HGF)0100 StatID EXPOS HEALTH : 2022 2023-10-27 IF >= 5 StatID:(DE-HGF)9905 StatID EXPOS HEALTH : 2022 2023-10-27 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2023-10-27 DEAL Springer StatID:(DE-HGF)3002 StatID 2023-10-27 ger DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-10-27 OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)1060 StatID Current Contents - Agriculture, Biology and Environmental Sciences 2023-10-27 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-10-27 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-10-27 APC keys set APC PC:(DE-HGF)0000 Local Funding APC PC:(DE-HGF)0001 I:(DE-2719)1012001 AG Breteler Population Health Sciences 0 I:(DE-2719)5000071 AG Aziz Population & Clinical Neuroepidemiology 1 FullTexts journal VDB I:(DE-2719)1012001 I:(DE-2719)5000071 UNRESTRICTED APC