272137 20250127091538.0 pmc:PMC11393326 pmc 10.1038/s41598-024-72040-8 doi pmid:39266690 pmid altmetric:167423073 altmetric DZNE-2024-01132 English 600 Andac, Safa P:(DE-2719)9002130 0 dzne Navigation performance in glaucoma: virtual-reality-based assessment of path integration. [London] 2024 Macmillan Publishers Limited, part of Springer Nature article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1727089444_16291 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Navigation is essential for moving between locations in our daily lives. We investigated the relationship between visual impairment in glaucoma and path-integration-based navigation. Fourteen glaucoma and 15 controls underwent ophthalmological examination (including visual acuity (logMAR), visual field sensitivity (MD: mean deviation from matched reference cohort), and peripapillary retinal nerve fiber layer (pRNFL)). Both groups navigated physically in virtual reality (VR) environments during daylight and dawn conditions. Briefly, the participants traversed a path marked by three targets, subsequently pointing back to the path's origin. Outcome measures included (i) travel-time, (ii) pointing-time, and (iii) Euclidian-distance error between indicated and starting position. Robust linear regression was conducted between visual function outcomes of the better eye and VR outcome measures. Glaucoma patients showed increase in travel-time (by 8.2 ± 1.7 s; p = 0.002) and in pointing-time (by 5.3 ± 1.6 s; p = 0.016). Predictors were MD for all outcome measures (p < 0.01) and pRNFL for travel-time (p < 0.01). The results suggest that the effect of glaucoma on the elapsed time depends on disease progression, i.e. people with stronger visual impairment need more time. This uncertainty during everyday navigation tasks may adversely affect their quality of life. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Glaucoma Other Navigation Other Path integration Other Virtual reality Other Visual field Other Humans MeSH Female MeSH Male MeSH Virtual Reality MeSH Glaucoma: physiopathology MeSH Visual Acuity: physiology MeSH Middle Aged MeSH Visual Fields: physiology MeSH Aged MeSH Spatial Navigation: physiology MeSH Case-Control Studies MeSH Stolle, Francie P:(DE-2719)9003189 1 dzne Bernard, Matthieu P:(DE-2719)9002387 2 dzne Al-Nosairy, Khaldoon O 3 Wolbers, Thomas P:(DE-2719)2810583 4 dzne Hoffmann, Michael B 5 10.1038/s41598-024-72040-8 Vol. 14, no. 1, p. 21320 PERI:(DE-600)2615211-3 1 21320 Scientific reports 14 2024 2045-2322 http://pub.dzne.de/record/272137/files/DZNE-2024-01132%20SUP.pdf OpenAccess http://pub.dzne.de/record/272137/files/DZNE-2024-01132.pdf pdfa http://pub.dzne.de/record/272137/files/DZNE-2024-01132%20SUP.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/272137/files/DZNE-2024-01132.pdf?subformat=pdfa oai:pub.dzne.de:272137 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 0 P:(DE-2719)9002130 External Institute I:(DE-HGF)0 Extern 1 P:(DE-2719)9003189 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9002387 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2810583 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2024 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-24 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2023-08-24 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-08-24 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2023-08-24 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-08-24 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2023-08-24 JCR StatID:(DE-HGF)0100 StatID SCI REP-UK : 2022 2023-08-24 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2023-04-12T15:11:06Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2023-04-12T15:11:06Z WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2023-08-24 Fees StatID:(DE-HGF)0700 StatID 2023-08-24 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-24 IF < 5 StatID:(DE-HGF)9900 StatID 2023-08-24 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-08-24 Article Processing Charges StatID:(DE-HGF)0561 StatID 2023-08-24 DBCoverage StatID:(DE-HGF)1150 StatID Current Contents - Physical, Chemical and Earth Sciences 2023-08-24 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-24 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2023-08-24 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-24 I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 0 journal VDB UNRESTRICTED I:(DE-2719)1310002 FullTexts