272592 20250127091449.0 pmid:39409066 pmid 10.3390/ijms251910737 doi 1422-0067 ISSN 1661-6596 ISSN pmc:PMC11476365 pmc DZNE-2024-01213 540 Fischer, Thomas P:(DE-2719)9000370 0 Tumoricidal Activity and Side Effects of Radiolabeled Anti-NCAM [131I]-Iodine-ERIC1 in Neuroblastoma-Bearing Mice Basel 2024 Molecular Diversity Preservation International article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1729175535_2185 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Preliminary studies on a radioactive antibody against the neural cell adhesion molecule (NCAM) demonstrated a significant accumulation of [131I]I-ERIC1 in neuroblastoma tumor cells in mice. This study aims to validate the therapeutic efficacy and potential adverse effects of these radioactive immunoconjugates (RICs) in neuroblastoma-bearing mice. To determine the highest tolerated dose, healthy SCID mice received 1 to 22 MBq of [131I]I-ERIC1, with the survival time measured. Tumor response was evaluated by administering 0.8 to 22 MBq of [131I]I-ERIC1 to neuroblastoma-bearing mice and assessing tumor size and systemic toxicity through body weight, blood counts, and survival. It was observed that doses up to approximately 3 MBq per animal (150 MBq/kg) were well tolerated, whereas higher doses resulted in systemic toxicity and death. The neuroblastomas exhibited a dose-dependent response, with optimal therapeutic efficacy achieved at 1.8-2.5 MBq per animal (90-125 MBq/kg), significantly extending survival by a factor of five. The antibody ERIC1 is a promising vehicle for the transport of beta emitters into NCAM-positive tumor tissue. An optimal dosage of the [131I]I-ERIC1 antibody can be established with a balance of tumor-static effects and adverse effects, resulting in a marked extension of survival time. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Animals MeSH Neuroblastoma: pathology MeSH Neuroblastoma: metabolism MeSH Neuroblastoma: drug therapy MeSH Mice MeSH Iodine Radioisotopes: adverse effects MeSH Cell Line, Tumor MeSH Neural Cell Adhesion Molecules: metabolism MeSH Humans MeSH Mice, SCID MeSH Xenograft Model Antitumor Assays MeSH Immunoconjugates: pharmacology MeSH Female MeSH Antibodies, Monoclonal: therapeutic use MeSH Antibodies, Monoclonal: pharmacology MeSH Dietlein, Felix 0000-0002-6651-7155 1 Bongartz, Detlev 2 Klehr, Martin 3 Zimmermanns, Beate 0009-0009-2207-9657 4 Schmidt, Matthias 0000-0002-7519-8897 5 Mohr, Angela 6 Mohr, Fabian 0000-0001-7272-935X 7 Sudbrock, Ferdinand 8 Krapf, Philipp 9 Drzezga, Alexander P:(DE-2719)2811239 10 dzne Dietlein, Markus 0000-0003-0992-6099 11 Schomäcker, Klaus 12 Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 3.0 10.3390/ijms251910737 Vol. 25, no. 19, p. 10737 - PERI:(DE-600)2019364-6 19 10737 International journal of molecular sciences 25 2024 1422-0067 OpenAccess http://pub.dzne.de/record/272592/files/DZNE-2024-01213.pdf OpenAccess pdfa http://pub.dzne.de/record/272592/files/DZNE-2024-01213.pdf?subformat=pdfa oai:pub.dzne.de:272592 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 10 P:(DE-2719)2811239 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2024 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-08-25 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2023-08-25 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-08-25 JCR StatID:(DE-HGF)0100 StatID INT J MOL SCI : 2022 2023-08-25 IF >= 5 StatID:(DE-HGF)9905 StatID INT J MOL SCI : 2022 2023-08-25 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2023-07-07T16:31:47Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2023-07-07T16:31:47Z WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2023-08-25 Fees StatID:(DE-HGF)0700 StatID 2023-08-25 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-08-25 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-08-25 Article Processing Charges StatID:(DE-HGF)0561 StatID 2023-08-25 DBCoverage StatID:(DE-HGF)1150 StatID Current Contents - Physical, Chemical and Earth Sciences 2023-08-25 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-08-25 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2023-08-25 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-08-25 I:(DE-2719)1011202 AG Boecker Positron Emissions Tomography (PET) 0 journal VDB UNRESTRICTED I:(DE-2719)1011202 FullTexts