275863 20260105130717.0 pmid:40800877 pmid 10.1162/imag_a_00435 doi altmetric:172801692 altmetric pmc:PMC12320002 pmc DZNE-2025-00098 610 Ramadan, Dana 0 Macrovascular contributions to resting-state fMRI signals: A comparison between EPI and bSSFP at 9.4 Tesla Cambridge, MA 2025 MIT Press article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1736946308_13620 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The draining-vein bias of T2*-weighted sequences, like gradient echo echo-planar imaging (GRE-EPI), can limit the spatial specificity of functional MRI (fMRI). The underlying extravascular signal changes increase with field strength (B0) and the perpendicularity of draining veins to the main axis of B0, and are, therefore, particularly problematic at ultra-high field (UHF). In contrast, simulations showed that T2-weighted sequences are less affected by the draining-vein bias, depending on the amount of rephasing of extravascular signal. As large pial veins on the cortical surface follow the cortical folding tightly, their orientation can be approximated by the cortical orientation to B 0 → . In our work, we compare the influence of the cortical orientation to B 0 → on the resting-state fMRI signal of three sequences aiming to understand their macrovascular contribution. While 2D GRE-EPI and 3D GRE-EPI (both T2*-weighted) showed a high dependence on the cortical orientation to B 0 → , especially on the cortical surface, this was not the case for 3D balanced steady-state free precession (bSSFP) (T2/T1-weighted). Here, a slight increase of orientation dependence was shown in depths closest to white matter (WM). And while orientation dependence decreased with increased distance to the veins for both EPI sequences, no change in orientation dependence was observed in bSSFP. This indicates the low macrovascular contribution to the bSSFP signal, making it a promising sequence for layer fMRI at UHF. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Mueller, Sebastian 1 Stirnberg, Rüdiger P:(DE-2719)2810697 2 dzne Bosch, Dario 3 Ehses, Philipp P:(DE-2719)2812222 4 dzne Scheffler, Klaus 5 Bause, Jonas 6 10.1162/imag_a_00435 Vol. 3, p. imag_a_00435 PERI:(DE-600)3167925-0 imag_a_00435 Imaging neuroscience 3 2025 2837-6056 http://pub.dzne.de/record/275863/files/DZNE-2025-00098%20SUP.pdf OpenAccess http://pub.dzne.de/record/275863/files/DZNE-2025-00098.pdf pdfa http://pub.dzne.de/record/275863/files/DZNE-2025-00098%20SUP.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/275863/files/DZNE-2025-00098.pdf?subformat=pdfa oai:pub.dzne.de:275863 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810697 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2812222 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 2025 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2024-09-26T09:40:26Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2024-09-26T09:40:26Z OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2024-09-26T09:40:26Z Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-01-02 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-01-02 Fees StatID:(DE-HGF)0700 StatID 2025-01-02 I:(DE-2719)1013026 AG Stöcker MR Physics 0 I:(DE-2719)1040310 AG Reuter Artificial Intelligence in Medicine 1 journal VDB UNRESTRICTED I:(DE-2719)1013026 I:(DE-2719)1040310 FullTexts