278793 20260309111154.0 pmc:PMC12092561 pmc 10.1007/s00415-025-13089-x doi pmid:40392424 pmid 0367-004X ISSN 0012-1037 ISSN 0340-5354 ISSN 1432-1459 ISSN DZNE-2025-00629 English 610 Lehto, Annaliis P:(DE-2719)9002327 0 First author Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis. [Darmstadt] 2025 Steinkopff article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1748946576_5050 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder and a model for upper motor neuron degeneration, which is believed to begin in the primary motor cortex. However, clinical observation suggests that not all PLS cases show primary motor cortex glucose hypometabolism on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET). We aimed to assess the reliability of FDG-PET in identifying motor cortex hypometabolism over disease course in a sample of patients with PLS.Baseline FDG-PET data from nine consecutive PLS patients were analyzed. At least one follow up assessment was available for five patients. We extracted the average FDG-PET signal in the primary motor cortex and other motor regions and calculated the covariate-corrected z scores based on data of healthy controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.Among the nine patients evaluated, only four demonstrated glucose hypometabolism in the primary motor cortex across available baseline and follow up assessments. Glucose metabolism of motor regions declined over time in some patients, whereas others maintained stable levels despite a worsening in symptom severity.Primary motor cortex hypometabolism in PLS patients is less consistent than previously reported, and the absence of this hypometabolic sign should not be considered as irrefutable evidence against PLS in the diagnostic process. The findings of our study underline the heterogeneity of PLS, indicating that more precise diagnostic tools would be beneficial to confirm a PLS diagnosis at an earlier stage. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Cerebral glucose metabolism Other FDG-PET Other Primary lateral sclerosis Other Primary motor cortex Other Fluorodeoxyglucose F18 0Z5B2CJX4D NLM Chemicals Glucose IY9XDZ35W2 NLM Chemicals Humans MeSH Motor Cortex: metabolism MeSH Motor Cortex: diagnostic imaging MeSH Male MeSH Female MeSH Positron-Emission Tomography MeSH Middle Aged MeSH Aged MeSH Fluorodeoxyglucose F18 MeSH Glucose: metabolism MeSH Motor Neuron Disease: diagnostic imaging MeSH Motor Neuron Disease: metabolism MeSH Follow-Up Studies MeSH Schumacher, Julia P:(DE-2719)9002248 1 Kurth, Jens 0000-0001-6864-4513 2 Krause, Bernd J 3 Kasper, Elisabeth P:(DE-2719)9000419 4 dzne Teipel, Stefan P:(DE-2719)2000026 5 Prudlo, Johannes P:(DE-2719)2380559 6 Last author Initiative, Alzheimer’s Disease Neuroimaging 7 Collaboration Author 10.1007/s00415-025-13089-x Vol. 272, no. 6, p. 410 PERI:(DE-600)1421299-7 6 410 Journal of neurology 272 2025 0367-004X http://pub.dzne.de/record/278793/files/DZNE-2025-00629%20SUP.pdf OpenAccess http://pub.dzne.de/record/278793/files/DZNE-2025-00629.pdf pdfa http://pub.dzne.de/record/278793/files/DZNE-2025-00629%20SUP.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/278793/files/DZNE-2025-00629.pdf?subformat=pdfa #709 2600.00 Hybrid-OA 2026-03-09 DEAL oai:pub.dzne.de:278793 openaire open_access OpenAPC_DEAL driver VDB openCost dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9002327 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9002248 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9000419 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2000026 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2380559 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2025 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2024-12-10 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2024-12-10 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2024-12-10 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2024-12-10 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2024-12-10 OpenAccess StatID:(DE-HGF)0510 StatID JCR StatID:(DE-HGF)0100 StatID J NEUROL : 2022 2024-12-10 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2024-12-10 DEAL Springer StatID:(DE-HGF)3002 StatID 2024-12-10 ger DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2024-12-10 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2024-12-10 Peer Review StatID:(DE-HGF)0030 StatID ASC 2024-12-10 IF >= 5 StatID:(DE-HGF)9905 StatID J NEUROL : 2022 2024-12-10 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-10 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC Nationallizenz StatID:(DE-HGF)0420 StatID 2024-12-10 ger DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2024-12-10 APC keys set APC PC:(DE-HGF)0000 Local Funding APC PC:(DE-HGF)0001 I:(DE-2719)1510100 AG Teipel Clinical Dementia Research (Rostock /Greifswald) 0 I:(DE-2719)5000014 AG Storch Non-Motor Symptoms in Parkinson's disease 1 FullTexts journal VDB UNRESTRICTED I:(DE-2719)1510100 I:(DE-2719)5000014 APC