Journal Article (Review Article)

DZNE-2025-00650

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fluid biomarkers unveil signatures of pathological aging.

Hansen, N. ; Wiltfang, J. (Last author)DZNE*

2025
Elsevier Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.seizure.2024.05.019

Abstract: Aging is a multifaceted and highly varied process in the brain. Identifying aging biomarkers is one means of distinguishing pathological from physiological aging. The aim of this narrative review is to focus on two new developments in the field of fluid biomarkers and draw attention to this excellent tool for the early detection of potential brain pathologies that delay, alter, or enable physiological aging to become pathological. Pathological aging can lower the threshold for the development of specific diseases such as late-onset epilepsy. Fluid biomarkers can reveal pathological levels at an early stage and thus indicate disease processes in the brain that begin before symptoms develop; they thus differ from physiological aging.

Keyword(s): Humans (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Aging: pathology (MeSH) ; Aging: cerebrospinal fluid (MeSH) ; Epilepsy: cerebrospinal fluid (MeSH) ; Brain: pathology (MeSH) ; Blood biomarkers ; Fluid biomarkers ; Inflammaging ; Late-onset epilepsy ; Neural autoantibodies ; Pathological and physiological aging ; Biomarkers

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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