279184 20251223103529.0 10.1038/s44220-024-00361-8 doi DZNE-2025-00712 610 Bartrés-Faz, David 0000-0001-6020-4118 0 Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults London 2025 Nature Publishing Group UK article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1766399394_14400 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); N = 750) and older adult (71.1 ± 5.9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies. 899 - ohne Topic (POF4-899) G:(DE-HGF)POF4-899 POF4-899 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Demnitz-King, Harriet 0000-0002-7421-7101 1 Cabello-Toscano, María 2 Vaqué-Alcázar, Lídia 0000-0002-6776-6559 3 Saunders, Rob 4 Touron, Edelweiss 0000-0001-7906-934X 5 Cattaneo, Gabriele 6 Gonneaud, Julie 7 Klimecki-Lenz, Olga Maria P:(DE-2719)9002456 8 dzne Bargalló, Núria 9 Sánchez-Solana, Javier 10 Tormos, José M. 11 Chételat, Gäel 0000-0002-4889-7932 12 Pascual-Leone, Álvaro 0000-0001-8975-0382 13 Marchant, Natalie L. 0000-0003-0669-6910 14 André, Claire 15 Bachelet, Romain 16 Baez Lugo, Sebastian 17 Chocat, Anne 18 Collette, Fabienne 19 Coll-Padros, Nina 20 Dautricourt, Sophie 21 De La Sayette, Vincent 22 Delarue, Marion 23 Ferrand Devouge, Eglantine 24 Frison, Eric 25 Goldet, Karine 26 Jessen, Frank P:(DE-2719)2000032 27 dzne Krolak-Salmon, Pierre 28 Kuhn, Elizabeth P:(DE-2719)9002169 29 dzne Landeau, Brigitte 30 Lefranc, Valérie 31 Lutz, Antoine 32 Mezenge, Florence 33 Meiberth, Dix P:(DE-2719)9000940 34 dzne Michel, Laurence 35 Molinuevo, José Luis 36 Ourry, Valentin 37 Poisnel, Géraldine 38 Quillard, Anne 39 Rauchs, Géraldine 40 Salmon, Eric 41 Schild, Ann-Katrin 42 Schimmer, Corinne 43 Smagghe, Delphine 44 Smith, Rhonda 45 Schlosser, Marco 46 Vuilleumier, Patrik 47 Wallet, Cédrick 48 Walker, Zuzana 49 Whitfield, Tim 50 Wirth, Miranka P:(DE-2719)2814122 51 dzne 10.1038/s44220-024-00361-8 Vol. 3, no. 1, p. 92 - 103 PERI:(DE-600)3123130-5 1 92 - 103 Nature Mental Health 3 2025 2731-6076 OpenAccess http://pub.dzne.de/record/279184/files/DZNE-2025-00712.pdf OpenAccess pdfa http://pub.dzne.de/record/279184/files/DZNE-2025-00712.pdf?subformat=pdfa oai:pub.dzne.de:279184 openaire open_access driver dnbdelivery External Institute I:(DE-HGF)0 Extern 8 P:(DE-2719)9002456 External Institute I:(DE-HGF)0 Extern 27 P:(DE-2719)2000032 External Institute I:(DE-HGF)0 Extern 29 P:(DE-2719)9002169 External Institute I:(DE-HGF)0 Extern 34 P:(DE-2719)9000940 External Institute I:(DE-HGF)0 Extern 51 P:(DE-2719)2814122 DE-HGF Programmungebundene Forschung ohne Programm G:(DE-HGF)POF4-890 G:(DE-HGF)POF4-899 G:(DE-HGF)POF4 G:(DE-HGF)POF4-800 G:(DE-HGF)POF ohne Topic 0 OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-20 Hosted Content StatID:(DE-HGF)10000 StatID Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DEAL Nature StatID:(DE-HGF)3003 StatID 2024-12-20 ger UNRESTRICTED EXTERN4VITA FullTexts journal I:(DE-2719)1011102 I:(DE-2719)1710011 I:(DE-2719)1040260