279185 20260107144937.0 10.1162/imag_a_00065 doi altmetric:158314001 altmetric DZNE-2025-00713 610 Schaefer, Michael 0 The neural networks of touch observation Cambridge, MA 2024 MIT Press article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1751967169_3177 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Studies have consistently demonstrated that the mere observation of touch engages our own somatosensory cortices. However, a systematic evaluation of the involved networks is missing. Here, we present results of a meta-analytic connectivity modeling (MACM) approach based on clusters revealed by activation likelihood estimation (ALE) combined with resting-state analysis to detect networks subserving our ability to empathize with tactile experiences of other people. ALE analysis revealed 8 clusters in frontal, temporal, and parietal brain areas, which behavioral domain profiles predominantly refer to cognition and perception. The MACM analysis further identified distinct networks that are subserved by subcortical structures, revealed that all clusters involved in touch observation are connected to dorso-medial frontal and anterior cingulate cortex control regions, and showed that medial temporal lobe memory structures do not inform network activation during touch observation (confirmed by post hoc resting-state connectivity analyses). Our data highlight the importance of higher-level control areas and suggest only a minor role for past bodily experiences in the ad hoc perception of other people’s experiences. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Kuehn, Esther P:(DE-2719)9001179 1 dzne Schweitzer, Felix 2 Muehlhan, Markus 3 10.1162/imag_a_00065 Vol. 2, p. 1 - 16 PERI:(DE-600)3167925-0 1 - 16 Imaging neuroscience 2 2024 2837-6056 http://pub.dzne.de/record/279185/files/DZNE-2025-00713%20SUP.zip OpenAccess http://pub.dzne.de/record/279185/files/DZNE-2025-00713.pdf OpenAccess pdfa http://pub.dzne.de/record/279185/files/DZNE-2025-00713.pdf?subformat=pdfa oai:pub.dzne.de:279185 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9001179 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2024 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2024-09-26T09:40:26Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2024-09-26T09:40:26Z OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2024-09-26T09:40:26Z Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-01-02 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-01-02 Fees StatID:(DE-HGF)0700 StatID 2025-01-02 I:(DE-2719)1210000 AG Gasser Parkinson Genetics 0 journal VDB UNRESTRICTED I:(DE-2719)1210000 FullTexts